| A prospective study of the association between quantity and variety of fruit and vegetable intake and incident type 2 diabetes. | |
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MedLine Citation:
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PMID: 22474042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The association between quantity of fruit and vegetable (F&V) intake and risk of type 2 diabetes (T2D) is not clear, and the relationship with variety of intake is unknown. The current study examined the association of both quantity and variety of F&V intake and risk of T2D. RESEARCH DESIGN AND METHODS: We examined the 11-year incidence of T2D in relation to quantity and variety of fruit, vegetables, and combined F&V intake in a case-cohort study of 3,704 participants (n = 653 diabetes cases) nested within the European Prospective Investigation into Cancer and Nutrition-Norfolk study, who completed 7-day prospective food diaries. Variety of intake was derived from the total number of different items consumed in a 1-week period. Multivariable, Prentice-weighted Cox regression was used to estimate hazard ratios (HRs) and 95% CIs. RESULTS: A greater quantity of combined F&V intake was associated with 21% lower hazard of T2D (HR 0.79 [95% CI 0.62-1.00]) comparing extreme tertiles, in adjusted analyses including variety. Separately, quantity of vegetable intake (0.76 [0.60-0.97]), but not fruit, was inversely associated with T2D in adjusted analysis. Greater variety in fruit (0.70 [0.53-0.91]), vegetable (0.77 [0.61-0.98]), and combined F&V (0.61 [0.48-0.78]) intake was associated with a lower hazard of T2D, independent of known confounders and quantity of intake comparing extreme tertiles. CONCLUSIONS: These findings suggest that a diet characterized by a greater quantity of vegetables and a greater variety of both F&V intake is associated with a reduced risk of T2D. |
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Authors:
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Andrew J Cooper; Stephen J Sharp; Marleen A H Lentjes; Robert N Luben; Kay-Tee Khaw; Nicholas J Wareham; Nita G Forouhi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-04-03 |
Journal Detail:
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Title: Diabetes care Volume: 35 ISSN: 1935-5548 ISO Abbreviation: Diabetes Care Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-23 Completed Date: 2012-09-18 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
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Languages: eng Pagination: 1293-300 Citation Subset: IM |
Affiliation:
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MRCEpidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, U.K. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Body Mass Index Case-Control Studies Cohort Studies Diabetes Mellitus, Type 2 / diet therapy, prevention & control* Diet Records Eating Female Fruit* Humans Incidence Male Middle Aged Nutrition Surveys Prospective Studies Questionnaires Risk Factors Vegetables* |
| Grant Support | |
ID/Acronym/Agency:
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MC_UP_A100_1003//Medical Research Council; //British Heart Foundation; //Cancer Research UK; //Medical Research Council |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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