Document Detail


Prospective randomized trial of six-month versus nine-month therapy for intestinal tuberculosis.
MedLine Citation:
PMID:  19667282     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intestinal tuberculosis (TB) continues to be a common disease worldwide. However, the optimal duration of anti-TB medication has not been well established. We therefore compared the efficacy of 6-month and 9-month therapy in the treatment of intestinal TB. Ninety patients definitely diagnosed with intestinal TB were randomized into 6-month (n = 45) or 9-month (n = 45) treatment groups, prospectively. The primary end point was complete response, defined as endoscopic healing of active lesions. Patients were followed up monthly for 3 months after therapy initiation, then every 3 months until the end of therapy, and finally 1 year later. Relapse was assessed 1 year after the end of therapy by patient interview and colonoscopy. Baseline characteristics were similar in the 6-month and 9-month groups. Intention-to-treat analysis revealed no significant differences between the two groups in complete response (6-month group, 93.3%; 9-month group, 91.1%; P = 1.00) or recurrence rate (6-month group, 2.4%; 9-month group, 0.0%; P = 1.00). Median follow-up duration was 39 months in the 6-month group and 32 months in the 9-month group. No surgery was performed on any patient in either group. In conclusion, the 6-month therapy was as effective as 9-month therapy in patients with intestinal TB and may have the additional benefits of reduced treatment cost and increased compliance.
Authors:
Sang Hyoung Park; Suk-Kyun Yang; Dong-Hoon Yang; Kyung Jo Kim; Soon Man Yoon; Jae Won Choe; Byong Duk Ye; Jeong-Sik Byeon; Seung-Jae Myung; Jin-Ho Kim
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-08-10
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  53     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-22     Completed Date:  2009-12-14     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4167-71     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antitubercular Agents / therapeutic use*
Ethambutol / therapeutic use
Female
Humans
Isoniazid / therapeutic use
Male
Middle Aged
Pyrazinamide / therapeutic use
Rifampin / therapeutic use
Treatment Outcome
Tuberculosis, Gastrointestinal / drug therapy*
Young Adult
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 13292-46-1/Rifampin; 54-85-3/Isoniazid; 74-55-5/Ethambutol; 98-96-4/Pyrazinamide
Comments/Corrections

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