| A Prospective Randomized Controlled Study on Multiple Neoadjuvant Treatments for Patients With Stage IB2 to IIA Cervical Cancer. | |
| | |
MedLine Citation:
|
PMID: 22274319 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: Patients with stage IB2 to IIA cervical cancer have a poor survival regardless of what primary treatment is performed. We conducted a study to demonstrate whether neoadjuvant treatment could offer survival benefits to those patients. METHODS: Between January 2006 and December 2009, 123 patients with stage IB2 to IIA cervical cancer were enrolled and randomly assigned to receive 1 of the following 4 treatments: radical surgery alone (arm RS), brachytherapy with a total dose of 15Gy to point A followed by radical surgery (arm BT), intravenous chemotherapy with cisplatin 50 mg/m plus 5-fluorouracil 750 mg/m at a 2-week interval for 2 courses followed by radical surgery (arm IVCT), or intra-arterial chemotherapy with the same regimen as the IVCT arm followed by radical surgery (arm IACT). Two weeks after neoadjuvant treatment, all patients underwent evaluation for response and operability. Those who were not amenable to surgery received concurrent chemoradiotherapy. RESULTS: With a mean follow-up of 34.8 months, 120 patients were evaluable. Baseline characteristics were similarly distributed in the 4 arms. Clinical overall response rates were 61.3%, 42.9%, and 79.3% in the BT, IVCT, and IACT groups, respectively. Two patients achieved pathological complete response. Three-year progression-free survival rates were 70.7%, 66.3%, 81.5%, and 79.7% in the RS, BT, IVCT, and IACT arms, respectively (P = 0.354). Three-year overall survival was 73.3%, 68.3%, 82.9% and 80.4%, respectively (P = 0.431). Multivariate analysis showed that only lymph node status correlated with progression-free survival. CONCLUSIONS: Neoadjuvant treatment had no significant impact on the outcomes of patients with stage IB2 to IIA cervical cancer. |
| | |
Authors:
|
Hao Wen; Xiaohua Wu; Ziting Li; Huaying Wang; Rongyu Zang; Min Sun; Xiao Huang; Zhiyi Zhang; Shumo Cai |
Related Documents
:
|
22450929 - Efficacy and safety of gemcitabine-docetaxel combination therapy for recurrent or refra... 3353619 - Soft-tissue sarcoma: initial characteristics and prognostic factors in patients with an... 3191459 - Primary peripheral neuroepithelioma of the orbit with intracranial extension. 22369429 - Adam8 in squamous cell carcinoma of the head and neck: a retrospective study. 15057149 - Synovial sarcoma prognostic factors and patterns of failure. 9057599 - Radiotherapy in soft tissue sarcoma of the extremities. 3301089 - Non-hodgkin's lymphoma of the head and neck: prognostic factors. 22450929 - Efficacy and safety of gemcitabine-docetaxel combination therapy for recurrent or refra... 7590569 - Surgical treatment and prognostic variables of hepatocellular carcinoma in 122 cirrhotics. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 22 ISSN: 1525-1438 ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 296-302 Citation Subset: IM |
Affiliation:
|
Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center; and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Correlation between body mass index and prevalence of hereditary nonpolyposis colorectal cancer in k...
Next Document: Temporal trends in the frequency of hydatidiform mole in lombardy, northern Italy, 1996-2008.