Document Detail

A prospective population study of resting heart rate and peak oxygen uptake (the HUNT Study, Norway).
MedLine Citation:
PMID:  23028740     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We assessed the prospective association of resting heart rate (RHR) at baseline with peak oxygen uptake (VO(2peak)) 23 years later, and evaluated whether physical activity (PA) could modify this association.
BACKGROUND: Both RHR and VO(2peak) are strong and independent predictors of cardiovascular morbidity and mortality. However, the association of RHR with VO(2peak) and modifying effect of PA have not been prospectively assessed in population studies.
METHODS: In 807 men and 810 women free from cardiovascular disease both at baseline (1984-86) and follow-up 23 years later, RHR was recorded at both occasions, and VO(2peak) was measured by ergospirometry at follow-up. We used Generalized Linear Models to assess the association of baseline RHR with VO(2peak), and to study combined effects of RHR and self-reported PA on later VO(2peak).
RESULTS: There was an inverse association of RHR at baseline with VO(2peak) (p<0.01). Men and women with baseline RHR greater than 80 bpm had 4.6 (95% confidence interval [CI], 2.8 to 6.3) and 1.4 (95% CI, -0.4 to 3.1) lower VO(2peak) at follow-up compared with men and women with RHR below 60 bpm at baseline. We found a linear association of change in RHR with VO(2peak) (p=0.03), suggesting that a decrease in RHR over time is likely to be beneficial for cardiovascular fitness. Participants with low RHR and high PA at baseline had higher VO(2peak) than inactive people with relatively high RHR. However, among participants with relatively high RHR and high PA at baseline, VO(2peak) was similar to inactive people with relatively low RHR.
CONCLUSION: RHR is an important predictor of VO(2peak), and serial assessments of RHR may provide useful and inexpensive information on cardiovascular fitness. The results suggest that high levels of PA may compensate for the lower VO(2peak) associated with a high RHR.
Javaid Nauman; Stian Thoresen Aspenes; Tom Ivar Lund Nilsen; Lars J Vatten; Ulrik Wisløff
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-18
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-02-26     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e45021     Citation Subset:  IM    
K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
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MeSH Terms
Follow-Up Studies
Heart Rate / physiology*
Middle Aged
Motor Activity
Oxygen Consumption / physiology*
Prospective Studies
Rest / physiology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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