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A Prospective Population-Based Cohort Study Of The Prevalence, Incidence And Impact Of Obsessive-Compulsive Symptomatology.
MedLine Citation:
PMID:  23205952     Owner:  NLM     Status:  Publisher    
Abstract Objective: Prospective longitudinal studies of obsessive-compulsive disorder (OCD) and sub-diagnostic obsessive-compulsive symptomatology in the non-clinical population, using age-defined cohorts, are rare. This study aimed to investigate the effect of OC symptoms on distress and psychosocial function and the effect of early-onset OC symptoms. Methods: 591 subjects drawn from the general population of Zurich, Switzerland were interviewed seven times between 1979 (at age 20/21) and 2008 (age 49/50). Data for socio-demographic variables and psychosocial impairment was also collected and compared with a control-group without OC symptoms drawn from the same population. Results: The unweighted cumulative one-year rate of OCD in this sample was 5.1% and 21.7% reported some degree of clinically-relevant OC symptomatology (OCD or OCS). OCD appeared more prevalent in females whereas OCS and OC symptoms were more prevalent in males. The weighted cumulative prevalence rates, representative of the general population, for OCD, OCS and OC symptoms were 3.5%, 9.7%, and 11.2%, respectively. We could not identify OCD occurring before the age of 10years, though sub-threshold cases were reported as early as age 2years, whereas by the age of 22years, around two thirds of OCD cases had emerged and no new cases developed OCD after around 37years. Males were statistically significantly younger than females at onset of any OC symptomatology Conclusions: Clinically-relevant OC syndromes start early and are associated with substantial distress, treatment-seeking activity and in the case of OCD, functional disability.
Naomi A Fineberg; Michael P Hengartner; Carmel E Bergbaum; Tim Gale; Alex Gamma; Vladeta Ajdacic-Gross; Wulf Rössler; Jules Angst
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  International journal of psychiatry in clinical practice     Volume:  -     ISSN:  1471-1788     ISO Abbreviation:  Int J Psychiatry Clin Pract     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709509     Medline TA:  Int J Psychiatry Clin Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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