Document Detail

A Prospective Longitudinal Survey of Erectile Dysfunction in Patients with Localized Prostate Cancer Treated with Permanent Prostate Brachytherapy.
MedLine Citation:
PMID:  23017516     Owner:  NLM     Status:  Publisher    
PURPOSE: Few studies have evaluated changes in erectile function (EF) over time before and after prostate brachytherapy (PB) using the International Index of Erectile Function (IIEF)-15. IIEF-15 is a sensitive and validated tool for the evaluation of male sexual dysfunction. In this prospective study, the natural history of EF after PB without supplemental therapies (external beam radiotherapy, phosphodiesterase-5 inhibitors, and androgen deprivation therapy) was assessed using IIEF-15 questionnaires. MATERIALS AND METHODS: We identified 119 patients who were followed-up for at least 12 months after PB between 2004 and 2010. Sexual status and EF status were assessed before PB (baseline), and 3, 6, 12, 18, 24, and 36 months postoperatively using IIEF-15 questionnaires. RESULTS: The mean total IIEF score, EF domain, orgasmic function domain, sexual desire domain, and intercourse satisfaction domain scores at 3 months after PB were significantly lower than those at baseline (p<0.05) and remained lower until 36 months after PB. Of the 48 patients who had EF domain score ≥11 at baseline, EF was maintained for 12 months after PB in 16 men (33.3%). There were no significant differences in clinical features except between ages of patients who could maintain EF domain score and their counterparts 12 months after PB. Multivariate analysis demonstrated that age ≥70 was the only predictive factor for exacerbating EF after PB (p=0.035). CONCLUSIONS: The findings indicate that there was a global decrease in all domains of the IIEF score 12 months after PB and that patient age may influence PB-related potency preservation.
Masashi Matsushima; Eiji Kikuchi; Takahiro Maeda; Jun Nakashima; Akitomo Sugawara; Toshiyuki Ando; Ryuichi Mizuno; Hirohiko Nagata; Akira Miyajima; Naoyuki Shigematsu; Mototsugu Oya
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-24
Journal Detail:
Title:  The Journal of urology     Volume:  -     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
Department of Urology, Keio University School of Medicine, Tokyo, Japan.
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