|A prospective cohort study of the prevalence of growth, facial, and central nervous system abnormalities in children with heavy prenatal alcohol exposure.|
|PMID: 22823161 Owner: NLM Status: MEDLINE|
|BACKGROUND: Most children who are exposed to large quantities of alcohol in utero do not develop fetal alcohol syndrome (FAS). Population-based prospective data on the risk of developing components of fetal alcohol spectrum disorders (FASD), however, are limited.
METHODS: This was a prospective cohort study of 9,628 women screened during their first prenatal appointment in Chile, which identified 101 who consumed at least 4 drinks/d (exposed) matched with 101 women with no reported alcohol consumption during pregnancy (unexposed). Detailed alcohol consumption data were collected during the pregnancy. Children were evaluated up to 8.5 years of age by clinicians masked to exposure status.
RESULTS: One or more functional central nervous system abnormalities were present in 44.0% (22/50) of the exposed children compared to 13.6% (6/44) of the unexposed (p = 0.002). Growth restriction was present in 27.2% (25/92) of the exposed and 12.5% (12/96) of the unexposed (p = 0.02). Abnormal facial features were present in 17.3% (14/81) of the exposed children compared to 1.1% (1/89) of the unexposed children (p = 0.0002) by direct examination. Of the 59 exposed children with data available to detect at least 1 abnormality, 12 (20.3%) had no abnormalities. Binge drinking from conception to recognition of pregnancy (OR = 1.48 per day, 95% CI: 1.15 to 1.91, p = 0.002) and after recognition of pregnancy (OR= 1.41 per day, 95% CI: 1.01 to 1.95, p = 0.04) and total number of drinks consumed per week from conception to recognition of pregnancy (OR = 1.02 per drink, 95% CI: 1.01 to 1.04, p = 0.0009) were significantly associated with abnormal child outcome.
CONCLUSIONS: After exposure to heavy alcohol consumption during pregnancy, 80% of children had 1 or more abnormalities associated with alcohol exposure. Patterns of alcohol use that posed the greatest risk of adverse outcomes were binge drinking and high total weekly intake. Functional neurologic impairment occurred most frequently and may be the only sign to alert physicians to prenatal alcohol exposure.
|Devon Kuehn; Sofía Aros; Fernando Cassorla; Maria Avaria; Nancy Unanue; Cecilia Henriquez; Karin Kleinsteuber; Barbara Conca; Alejandra Avila; Tonia C Carter; Mary R Conley; James Troendle; James L Mills|
|Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-07-23|
|Title: Alcoholism, clinical and experimental research Volume: 36 ISSN: 1530-0277 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 2012 Oct|
|Created Date: 2012-10-02 Completed Date: 2013-07-12 Revised Date: 2014-10-15|
Medline Journal Info:
|Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: England|
|Languages: eng Pagination: 1811-9 Citation Subset: IM|
|Copyright © 2012 by the Research Society on Alcoholism.|
|APA/MLA Format Download EndNote Download BibTex|
Alcohol Drinking / adverse effects*, epidemiology*
Birth Weight / drug effects*, physiology
Fetal Alcohol Spectrum Disorders / diagnosis, epidemiology
Frontal Lobe / abnormalities*, drug effects*, growth & development
Muscular Atrophy / chemically induced, diagnosis, epidemiology
Nervous System Malformations / chemically induced, diagnosis, epidemiology
Prenatal Exposure Delayed Effects / chemically induced, diagnosis, epidemiology*
|ZIA HD008802-03/HD/NICHD NIH HHS; ZIA HD008802-04/HD/NICHD NIH HHS; ZIA HD008802-05/HD/NICHD NIH HHS; ZIA HD008802-06/HD/NICHD NIH HHS; ZIA HD008802-07/HD/NICHD NIH HHS|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Optogenetic inhibition of cocaine seeking in rats.
Next Document: Intranasal administration of the TLR2-agonist Pam2Cys provides rapid protection against influenza in...