Document Detail

Prorenin levels in retinopathy of prematurity.
MedLine Citation:
PMID:  17317409     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate serum prorenin levels in preterm infants with or without retinopathy of prematurity (ROP). DESIGN: Noncomparative retrospective case control study. METHODS: Serum prorenin levels in children with a gestational age younger than 36 weeks were measured with antibody-activating direct enzyme kinetic assay. RESULTS: The mean prorenin concentrations were higher in preterm infants with ROP than in infants without ROP at every time point: from 26 to 30 weeks, 2326 +/- 334 microg/ml (mean +/- SE [standard error]) (n = 3) and 1164 +/- 234 microg/ml (n = 3), respectively (P < .05); from 31 to 35 weeks, 1760 +/- 496 microg/ml (n = 10) and 957.1 +/- 139 microg/ml (n = 25) (P < .05); from 36 to 40 weeks, 958.2 +/- 194.2 microg/ml (n = 23) and 470.1 +/- 32.6 microg/ml (n = 67) (P < .01); and from 41 to 45 weeks, 575.8 +/- 148.4 (n = 9) and 385.6 +/- 47.9 (n = 13), which is not significantly different. CONCLUSIONS: Prorenin levels in preterm infants can predict which infants will develop ROP.
Harumasa Yokota; Taiji Nagaoka; Fumihiko Mori; Taiichi Hikichi; Hiromichi Hosokawa; Hiroshi Tanaka; Yuichi Ishida; Fumiaki Suzuki; Akitoshi Yoshida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-28
Journal Detail:
Title:  American journal of ophthalmology     Volume:  143     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-3     Citation Subset:  AIM; IM    
Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan.
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MeSH Terms
Case-Control Studies
Gestational Age
Infant, Newborn
Infant, Premature / blood
Renin / blood*
Retinopathy of Prematurity / blood*,  classification
Retrospective Studies
Reg. No./Substance:

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