| Propylthiouracil-induced agranulocytosis in the third trimester of pregnancy. | |
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MedLine Citation:
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PMID: 20664427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Thionamide-induced agranulocytosis in pregnancy is a rare event that poses unique therapeutic challenges. CASE: A 37-year-old woman developed agranulocytosis while taking propylthiouracil in the third trimester. After she took broad-spectrum antibiotics and discontinued propylthiouracil, her neutrophil counts recovered. She was initially managed expectantly but later underwent an uncomplicated total thyroidectomy at 35 weeks of gestation because of patient choice coupled with worsening thyrotoxicosis. CONCLUSION: In circumstances in which thionamides are contraindicated, management options of hyperthyroidism in pregnancy are limited. The proximity to term in the third trimester makes expectant management an attractive approach when maternal thyroid indices are stable, allowing for a choice of postpartum therapies without the worry of fetal implications. However, this strategy carries risks, and thyroidectomy in the third trimester can be a safe alternative. |
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Authors:
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Ally Murji; Mara L Sobel; Denice S Feig; Mathew Sermer |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 116 Suppl 2 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 485-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Agranulocytosis / chemically induced*, therapy Antithyroid Agents / adverse effects* Female Graves Disease / drug therapy*, surgery Humans Pregnancy Pregnancy Complications, Hematologic / chemically induced* Pregnancy Trimester, Third Propylthiouracil / adverse effects* Thyroidectomy |
| Chemical | |
Reg. No./Substance:
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0/Antithyroid Agents; 51-52-5/Propylthiouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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