| Propylthiouracil-induced Antineutrophil Cytoplasmic Antibody (ANCA)-associated Renal Vasculitis Versus Primary ANCA-associated Renal Vasculitis: A Comparative Study. | |
| | |
MedLine Citation:
|
PMID: 22247359 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: Renal involvement is frequently present in primary antineutrophil cytoplasmic antibody-associated small-vessel vasculitis (AAV) as well as propylthiouracil (PTU)-induced AAV. We analyzed the characteristics of patients with PTU-induced AAV with renal involvement and investigated the differences of the 2 diseases. METHODS: Thirty-six patients with PTU-induced AAV, diagnosed from 1997 to 2010, were enrolled for study. Their data were compared with those of 174 patients with primary AAV diagnosed at the same time. Renal involvement was present in all patients. RESULTS: There was a prominent proportion of young women with PTU-induced AAV (p < 0.01). They had lower levels of proteinuria and serum creatinine and higher estimated glomerular filtration rate (p < 0.01, p < 0.01, and p < 0.01, respectively). Clinical immunological abnormalities were less severe in patients with PTU-induced AAV. Patients with PTU-induced AAV had less organ involvement and lower Birmingham Vasculitis Assessment Score than patients with primary AAV (p < 0.01). Renal biopsies showed a lower proportion of glomeruli with crescents (p < 0.01). Interstitial inflammation was less severe in patients with PTU-induced AAV (p < 0.05). Similarly, interstitial fibrosis and tubular atrophy were less severe in patients with PTU-induced AAV (p < 0.01, p < 0.05, respectively). Renal survival and total survival were better in patients with PTU-associated vasculitis (p < 0.05, p = 0.01). CONCLUSION: Clinical and histopathological abnormalities were less severe in patients with PTU-induced AAV and most of them had a good prognosis. |
| | |
Authors:
|
Yong-Xi Chen; Wen Zhang; Xiao-Nong Chen; Hai-Jin Yu; Li-Yan Ni; Jing Xu; Xiao-Xia Pan; Hong Ren; Nan Chen |
Related Documents
:
|
22333889 - Serum uric acid levels in patients with multiple sclerosis: a meta-analysis. 21930409 - The prevalence and impact of scoliosis in pompe disease: lessons learned from the pompe... 22595389 - The prevalence of peripheral neuropathy in hemodialysis patients. 21670439 - A multicenter assessment of cervical cord atrophy among ms clinical phenotypes. 21679709 - Distal esophageal spasm in high-resolution esophageal pressure topography: defining cli... 15784449 - Optimization of the therapeutic procedure during ldl-apheresis--a computerized model. 21373299 - The use of capnometry to predict arterial partial pressure of co(2) in non-intubated br... 10853709 - Low dose (1 microg) adrenocorticotropin stimulation test in the evaluation of hypothala... 18612769 - Acute myeloid leukemia induced by mitoxantrone treatment for aggressive multiple sclero... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-15 |
Journal Detail:
|
Title: The Journal of rheumatology Volume: - ISSN: 0315-162X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the Department of Nephrology, Shanghai Ruijin Hospital affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Utility of Interferon-? as a Biomarker in Central Neuropsychiatric Involvement in Systemic Lupus Ery...
Next Document: Remission in Early Rheumatoid Arthritis: Predicting Treatment Response.