| Propylthiouracil-induced Anti-neutrophil Cytoplasmic Antibodies and Agranulocytosis together with Granulocyte Colony-stimulating Factor Induced Sweet's Syndrome in a Patient with Graves' Disease. | |
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MedLine Citation:
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PMID: 21921379 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Propylthiouracil (PTU) is an antithyroid drug which is known to cause drug-induced vasculitis. PTU is implicated in 80-90% of cases of anti-neutrophil cytoplasm circulating antibody (ANCA)-associated vasculitis caused by anti-thyroid drugs which induce ANCA production. Sweet's syndrome is characterized by fever, leucocytosis, neutrophilia and the sudden onset of painful skin lesions. The pathology of the disease is still unclear. Cytokine dysregulation including interleukin-6 and endogenous granulocyte colony-stimulating factor (G-CSF) are thought to play a role in the pathogenesis of Sweet's syndrome. PTU and G-CSF are known to cause Sweet's syndrome and other neutrophilic dermatosis. The presence of ANCA can have a diagnostic value in Sweet's syndrome. Systemic corticosteroids are the first-line therapy for both diseases. Here we report a female patient with Graves' disease who developed ANCA and Sweet's syndrome after using PTU and G-CSF. |
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Authors:
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Celik Ozlem; Buyuktas Deram; Sevinc Mustafa; Tascilar Koray; Demirkesen Cuyan; Tasan Ertugrul |
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Publication Detail:
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Type: Journal Article Date: 2011-09-15 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 50 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 1973-6 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Department of Internal Medicine, Cerrahpasa Medical School, University of Istanbul, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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