Document Detail

Propylene glycol as a cause of an elevated serum osmolality.
MedLine Citation:
PMID:  495568     Owner:  NLM     Status:  MEDLINE    
Two severely burned patients experienced the onset of marked hyperosmolality during topical treatment with a cream containing silver sulfadiazine as an antimicrobial agent. Serum samples from both patients were studied for the presence of substances absorbed from the vehicle of the cream. Prophylene glycol, in concentrations which were high enough to account for the difference between calculated and measured osmolality, was demonstrated in the sera of these patients by gas chromatography.
L Bekeris; C Baker; J Fenton; D Kimball; E Bermes
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  72     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1979-12-20     Completed Date:  1979-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  633-6     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Topical
Burns / blood*,  drug therapy
Osmolar Concentration*
Propylene Glycols / adverse effects*
Silver Sulfadiazine / administration & dosage
Vehicles / adverse effects
Reg. No./Substance:
0/Propylene Glycols; 0/Vehicles; 22199-08-2/Silver Sulfadiazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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