| Proprotein convertase subtilisin/kexin type 9: A new target molecule for gene therapy. | |
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MedLine Citation:
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PMID: 22311433 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel target for controlling plasma levels of low-density lipoprotein cholesterol (LDL-C) and decreasing the risk of cardiovascular diseases. At present it is clear that the major classes of commonly prescribed lipid-lowering medications increase serum PCSK9 levels and fail to protect a significant percentage of patients from cardiovascular events. Therefore development of new LDL-C lowering medications that either do not increase circulating PCSK9 levels or work through inhibition of PCSK9 expression and protease activity is a highly desirable approach to overcome hypercholesterolemia. Since there are several agents which are being evaluated in human preclinical and clinical trials, this review summarizes current therapeutic strategies targeting PCSK9, including specific antibodies, antisense oligonucleotides, small interfering RNAs (siRNAs) and other small-molecule inhibitors. |
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Authors:
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Anna Banaszewska; Michal Piechota; Robert Plewa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-7 |
Journal Detail:
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Title: Cellular & molecular biology letters Volume: - ISSN: 1689-1392 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607427 Medline TA: Cell Mol Biol Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Animal Physiology and Development, Adam Mickiewicz University, 89 Umultowska St., 61-614, Poznan, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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