Document Detail

Proprotein Convertase Subtilisin Kexin9 (PCSK9): A Novel Target For Cholesterol Regulation.
MedLine Citation:
PMID:  22519528     Owner:  NLM     Status:  Publisher    
Proprotein Convertase Subtilisin Kexin9 (PCSK9), originally called Neural Apoptosis-Regulated Convertase1 (NARC1), is the latest member of mammalian subtilase super-family. Since its discovery in 2003, it has drawn significant attention because of its function in the degradation of Low Density Lipoprotein Receptor (LDL-R). LDL-R removes circulating LDL-cholesterol (LDL-C) in the blood. Increased level of PCSK9 functional activity will lead to an accumulation of cholesterol in the blood - a high risk factor for cardiovascular disease. This is confirmed by PCSK9 knock out and transgenic animals, various biochemical and clinical studies involving "gain and loss of function" genetic mutations of PCSK9 found in various subset of populations. Owing to this finding, development of strategies for inhibition of PCSK9 function has drawn significant research interest for therapeutic intervention of hypercholesterolemia. Thus PCSK9 is a target for the development of new cholesterol lowering drugs.
Ajoy Basak; Heather Palmar-Smith; Priyambada Mishra
Related Documents :
24534508 - Amylase addition increases starch ruminal digestion in first-lactation cows fed high an...
1298 - Effect of normal and ulcer-type diet on the acidity of gastric contents in patients wit...
8550858 - The effect of a commercially available triclosan-containing toothpaste compared to a so...
25409498 - The three-dimensional morphological effects of captivity.
6168288 - Dietary regulation of pancreatic protein synthesis. ii. kinetics of adaptation of prote...
9250098 - Fitness, fatness, and the effect of training assessed by magnetic resonance imaging and...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Protein and peptide letters     Volume:  -     ISSN:  1875-5305     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441434     Medline TA:  Protein Pept Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Chronic Disease Program, Regional Protein Chemistry Center, Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa, ON K1Y 4E9, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Trait emotional intelligence and mental distress: The mediating role of positive and negative affect...
Next Document:  Effect of Amidation on the Antimicrobial Peptide Aurein 2.5 from Australian Southern Bell Frogs.