| Proprioceptive neuropathy affects normalization of the H-reflex by exercise after spinal cord injury. | |
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MedLine Citation:
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PMID: 19913536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The H-reflex habituates at relatively low frequency (10 Hz) stimulation in the intact spinal cord, but loss of descending inhibition resulting from spinal cord transection reduces this habituation. There is a return towards a normal pattern of low-frequency habituation in the reflex activity with cycling exercise of the affected hind limbs. This implies that repetitive passive stretching of the muscles in spinalized animals and the accompanying stimulation of large (Group I and II) proprioceptive fibers has modulatory effects on spinal cord reflexes after injury. To test this hypothesis, we induced pyridoxine neurotoxicity that preferentially affects large dorsal root ganglia neurons in intact and spinalized rats. Pyridoxine or saline injections were given twice daily (IP) for 6 weeks and half of the spinalized animals were subjected to cycling exercise during that period. After 6 weeks, the tibial nerve was stimulated electrically and recordings of M and H waves were made from interosseous muscles of the hind paw. Results show that pyridoxine treatment completely eliminated the H-reflex in spinal intact animals. In contrast, transection paired with pyridoxine treatment resulted in a reduction of the frequency-dependent habituation of the H-reflex that was not affected by exercise. These results indicate that normal Group I and II afferent input is critical to achieve exercise-based reversal of hyper-reflexia of the H-reflex after spinal cord injury. |
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Authors:
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Karen Ollivier-Lanvin; Benjamin E Keeler; Rachel Siegfried; John D Houlé; Michel A Lemay |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-11-11 |
Journal Detail:
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Title: Experimental neurology Volume: 221 ISSN: 1090-2430 ISO Abbreviation: Exp. Neurol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-02-16 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 198-205 Citation Subset: IM |
Affiliation:
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Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Disease Models, Animal Electric Stimulation / methods Electromyography / methods Exercise Therapy / methods* Female Ganglia, Spinal / pathology H-Reflex / physiology* Nerve Fibers, Myelinated / drug effects, pathology, physiology* Neurons / drug effects Neurotoxicity Syndromes / etiology, pathology, physiopathology Proprioception / physiology* Pyridoxine / adverse effects, pharmacology Rats Rats, Sprague-Dawley Rats, Wistar Reaction Time / drug effects, physiology Spinal Cord Injuries / pathology, physiopathology*, rehabilitation* |
| Grant Support | |
ID/Acronym/Agency:
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NS007440/NS/NINDS NIH HHS; P01 NS055976/NS/NINDS NIH HHS; P01 NS055976-03/NS/NINDS NIH HHS; P01 NS055976-030003/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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65-23-6/Pyridoxine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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