Document Detail


Propranolol and the ventilatory response to hypoxia and hypercapnia in normal man.
MedLine Citation:
PMID:  720003     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The effect on respiration of a single dose of propranolol has been studied in normal subjects. 2. The degree of beta-adrenoreceptor blockade was assessed in terms of the impaired heart-rate response to progressive exercise and the plasma propranolol concentration. 3. No effect of propranolol was demonstrated on either the ventilatory response to rebreathing CO2 in hyperoxia, or the response to progressive isocapnic hypoxia. Simple indices of maximal expiratory flow (FEV 1.0% and PEFR) were also unchanged. 4. The absence of any effect of propranolol on the chemical control of breathing in man is discussed in relation to the conflicting literature.
Authors:
J M Patrick; J Tutty; S B Pearson
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine     Volume:  55     ISSN:  0301-0538     ISO Abbreviation:  Clin Sci Mol Med     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-02-26     Completed Date:  1979-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367540     Medline TA:  Clin Sci Mol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  491-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbon Dioxide*
Female
Heart Rate / drug effects
Humans
Male
Oxygen*
Propranolol / blood,  pharmacology*
Pulmonary Ventilation
Respiration / drug effects*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 525-66-6/Propranolol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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