Document Detail


Propranolol transiently inhibits reinstatement of nicotine-seeking behaviour in rats.
MedLine Citation:
PMID:  18832430     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Noradrenergic transmission has been implicated in the affective component of relapse to tobacco smoking. Evidence in human and laboratory animals showed that smoking or nicotine administration may cause changes of the noradrenergic system resulting in hyperactivity in this system after cessation. It has been hypothesised that the anti-adrenergic beta-blocker propranolol may decrease affective activation and arousal observed during drug withdrawal or cue-induced relapse. The aim of the present work was to test the effects of propranolol pre-treatment in a rat model of nicotine cue-induced relapse to nicotine seeking. We also tested the effects of propranolol on food cue-induced reinstatement of food seeking in rats trained on food self-administration. Propranolol transiently inhibited nicotine cue-induced reinstatement. The inhibitory effect of propranolol reached a peak after 30 min from the beginning of the reinstatement session and then it declined until it was completely absent at the end of the 3-h session. This inhibitory effect of propranolol was not observed when the drug was tested versus reinstatement with food cues. The present study suggests a weak effect of propranolol to counteract nicotine cue-induced reinstatement of nicotine seeking. Therefore, these findings do not support a potential use of propranolol for prevention of smoking relapse.
Authors:
C Chiamulera; V Tedesco; L Zangrandi; C Giuliano; G Fumagalli
Publication Detail:
Type:  Journal Article     Date:  2008-10-02
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  24     ISSN:  1461-7285     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-06-03     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  389-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Animals
Behavior, Addictive / prevention & control*
Disease Models, Animal
Extinction, Psychological / drug effects
Feeding Behavior / drug effects
Male
Nicotine / adverse effects*,  pharmacology
Nicotinic Agonists / pharmacology,  therapeutic use*
Propranolol / therapeutic use*
Rats
Rats, Sprague-Dawley
Recurrence / prevention & control
Reward
Self Administration
Smoking / drug therapy,  prevention & control*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Nicotinic Agonists; 54-11-5/Nicotine; 9Y8NXQ24VQ/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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