Document Detail

Propranolol stimulates the crosslinking of matrix components in skin from the aneurysm-prone blotchy mouse.
MedLine Citation:
PMID:  2704229     Owner:  NLM     Status:  MEDLINE    
Propranolol prevents or delays the formation of aortic aneurysms in both the lathyritic turkey and the Blotchy mouse models. This finding in the turkey is reported to be a direct effect on crosslinking of aortic collagen and elastin, independent of effects on pulse and blood pressure. The present work was performed to evaluate this hypothesis in the mouse model by studying the effect of propranolol on the insolubility of matrix proteins of skin, which would isolate the phenomenon from direct hemodynamic effects. Eight 6- to 8-week-old Blotchy mice were fed a diet containing 0.10% (w/w) propranolol for 12 weeks, and six Blotchy controls ate regular chow. At sacrifice the skins were extracted with 8 M urea, and the soluble and insoluble fractions were analyzed for hydroxyproline to determine the collagen contents. The elastin was estimated by subtracting the collagen from the insoluble fraction. There was a 147% increase in insoluble elastin with propranolol and a lesser increase of 54% in insoluble collagen. These results suggest that propranolol has a direct effect on crosslinking of matrix components.
C M Brophy; J E Tilson; M D Tilson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of surgical research     Volume:  46     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-16     Completed Date:  1989-05-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  330-2     Citation Subset:  IM    
Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510.
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MeSH Terms
Aortic Aneurysm / metabolism
Collagen / metabolism
Connective Tissue / drug effects*,  metabolism
Elastin / metabolism
Mice, Mutant Strains
Propranolol / pharmacology*
Skin / drug effects,  metabolism
Grant Support
R0-1 29325//PHS HHS
Reg. No./Substance:
525-66-6/Propranolol; 9007-34-5/Collagen; 9007-58-3/Elastin

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