Document Detail

Propranolol and skilled human performance.
MedLine Citation:
PMID:  935199     Owner:  NLM     Status:  MEDLINE    
In a double-blind crossover experiment 18 young men received on one occasion 6 doses of 40 mg propranolol and in the other placebo. Medication was given at 6 hour intervals. One hr after the last capsule was ingested subjects were measured with various physiological and behavioral tests. At the conclusion of testing mean plasma propranolol concentration was 67.6 ng/ml. Propranolol significantly reduced systolic blood pressure and heart rate. There was an increased variability on one behavioral measure but the results of other tests were not affected. The findings are discussed in terms of therapeutic use of this and other beta-adrenergic receptor blocking agents.
A A Landauer; L B Jellett; J Kirk
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  4     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-08-23     Completed Date:  1976-08-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
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MeSH Terms
Automobile Driving
Blood Pressure / drug effects
Choice Behavior / drug effects
Cognition / drug effects
Emotions / drug effects
Heart Rate / drug effects
Motor Skills / drug effects*
Propranolol / pharmacology*
Reaction Time / drug effects
Visual Acuity / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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