| Propranolol and skilled human performance. | |
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MedLine Citation:
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PMID: 935199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a double-blind crossover experiment 18 young men received on one occasion 6 doses of 40 mg propranolol and in the other placebo. Medication was given at 6 hour intervals. One hr after the last capsule was ingested subjects were measured with various physiological and behavioral tests. At the conclusion of testing mean plasma propranolol concentration was 67.6 ng/ml. Propranolol significantly reduced systolic blood pressure and heart rate. There was an increased variability on one behavioral measure but the results of other tests were not affected. The findings are discussed in terms of therapeutic use of this and other beta-adrenergic receptor blocking agents. |
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Authors:
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A A Landauer; L B Jellett; J Kirk |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 4 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1976 Mar |
Date Detail:
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Created Date: 1976-08-23 Completed Date: 1976-08-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 283-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Automobile Driving Blood Pressure / drug effects Choice Behavior / drug effects Cognition / drug effects Emotions / drug effects Heart Rate / drug effects Humans Male Motor Skills / drug effects* Propranolol / pharmacology* Reaction Time / drug effects Visual Acuity / drug effects |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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