| Propranolol reduces variceal pressure and wall tension in schistosomiasis presinusoidal portal hypertension. | |
| | |
MedLine Citation:
|
PMID: 19686417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIM: Although prophylaxis with beta-blockers has been shown to decrease variceal pressure and wall tension in cirrhotic patients, this has not been demonstrated in non-cirrhotic portal hypertension caused by Schistosoma mansoni infection. METHODS: Thirteen patients without history of previous gastrointestinal bleeding were included. All of them had high-risk esophageal varices at endoscopy. An endoscopic gauge and a high-frequency endoscopic ultrasonography miniprobe were used to assess transmural variceal pressure and wall tension before and after achieving beta-blockade with propranolol. RESULTS: Baseline variceal pressure decreased from 13.3 +/- 3.5 to 8.2 +/- 2.0 mmHg (P < 0.0001) and wall tension from 500.2 +/- 279.8 to 274.0 +/- 108.3 mg.mm(-1). The overall effect of propranolol on decreasing variceal pressure and wall tension expressed in percentage change in relation to baseline values was 35.7 +/- 18.4% and 35.9 +/- 26.7%, respectively (P = 0.9993). CONCLUSION: Propranolol significantly reduced variceal pressure and wall tension in schistosomiasis. |
| | |
Authors:
|
Alberto Queiroz Farias; Fabio Kassab; Evandra Cristina Vieira da Rocha; Valdin?lia Dos Santos Bomfim; Denise Cerqueira Paranagu? Vezozzo; Paulo Lisboa Bittencourt; Flair Jos? Carrilho |
Related Documents
:
|
8314637 - A compliant biological vascular prosthesis. 18549907 - Warfarin-induced bleeding complications - clinical presentation and therapeutic options. 3568957 - Vibration sensory thresholds depend on pressure of applied stimulus. 10643627 - Influence of pharmacological agents on portal hemodynamics: basis for its use in the tr... 6407317 - Neuromechanical properties in obese patients during carbon dioxide rebreathing. 3355737 - Measurement of arterial pressure using catheter-transducer systems. improvement using t... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of gastroenterology and hepatology Volume: 24 ISSN: 1440-1746 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-12-16 Completed Date: 2010-03-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
|
Languages: eng Pagination: 1852-6 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology, University of S?o Paulo School of Medicine, Brazil. albertofarias@terra.com.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
therapeutic use* Adult Animals Endosonography Esophageal and Gastric Varices / drug therapy*, parasitology, physiopathology Esophagoscopy Female Gastrointestinal Hemorrhage / parasitology, physiopathology, prevention & control* Humans Hypertension, Portal / drug therapy*, parasitology, physiopathology Male Middle Aged Pilot Projects Propranolol / therapeutic use* Schistosomiasis mansoni / complications, drug therapy*, physiopathology Treatment Outcome Venous Pressure / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Validation of model for end-stage liver disease score to serum sodium ratio index as a prognostic pr...
Next Document: Melatonin prevents peritoneal adhesions in rats.