Document Detail


Propranolol reduces variceal pressure and wall tension in schistosomiasis presinusoidal portal hypertension.
MedLine Citation:
PMID:  19686417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIM: Although prophylaxis with beta-blockers has been shown to decrease variceal pressure and wall tension in cirrhotic patients, this has not been demonstrated in non-cirrhotic portal hypertension caused by Schistosoma mansoni infection. METHODS: Thirteen patients without history of previous gastrointestinal bleeding were included. All of them had high-risk esophageal varices at endoscopy. An endoscopic gauge and a high-frequency endoscopic ultrasonography miniprobe were used to assess transmural variceal pressure and wall tension before and after achieving beta-blockade with propranolol. RESULTS: Baseline variceal pressure decreased from 13.3 +/- 3.5 to 8.2 +/- 2.0 mmHg (P < 0.0001) and wall tension from 500.2 +/- 279.8 to 274.0 +/- 108.3 mg.mm(-1). The overall effect of propranolol on decreasing variceal pressure and wall tension expressed in percentage change in relation to baseline values was 35.7 +/- 18.4% and 35.9 +/- 26.7%, respectively (P = 0.9993). CONCLUSION: Propranolol significantly reduced variceal pressure and wall tension in schistosomiasis.
Authors:
Alberto Queiroz Farias; Fabio Kassab; Evandra Cristina Vieira da Rocha; Valdin?lia Dos Santos Bomfim; Denise Cerqueira Paranagu? Vezozzo; Paulo Lisboa Bittencourt; Flair Jos? Carrilho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  24     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1852-6     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, University of S?o Paulo School of Medicine, Brazil. albertofarias@terra.com.br
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Adult
Animals
Endosonography
Esophageal and Gastric Varices / drug therapy*,  parasitology,  physiopathology
Esophagoscopy
Female
Gastrointestinal Hemorrhage / parasitology,  physiopathology,  prevention & control*
Humans
Hypertension, Portal / drug therapy*,  parasitology,  physiopathology
Male
Middle Aged
Pilot Projects
Propranolol / therapeutic use*
Schistosomiasis mansoni / complications,  drug therapy*,  physiopathology
Treatment Outcome
Venous Pressure / drug effects*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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