| Propranolol and the morning increase in sudden cardiac death: (the beta-blocker heart attack trial experience). | |
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MedLine Citation:
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PMID: 2239715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To provide insight into the protective effect of propranolol on mortality after myocardial infarction observed in the beta-Blocker Heart Attack Trial, the time of occurrence of sudden cardiac death was examined in this population. Between 5 A.M. and 11 A.M., 25 of the 56 total deaths (38%) occurred in the placebo patients compared with 11 of 45 (24%) in the propranolol patients. Excluding this period, there were nearly equal numbers of sudden cardiac deaths in the propranolol and placebo groups. This retrospective analysis suggests that beta blockade is protective during the morning hours when a surge of sympathetic activity may increase the risk of sudden cardiac death. |
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Authors:
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R W Peters |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of cardiology Volume: 66 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1990-12-13 Completed Date: 1990-12-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 57G-59G Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, University of Maryland, Baltimore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Circadian Rhythm* Death, Sudden / epidemiology* Double-Blind Method Humans Middle Aged Myocardial Infarction / drug therapy, mortality* Propranolol / therapeutic use* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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