Document Detail

Propranolol in the treatment of essential hypertension.
MedLine Citation:
PMID:  323525     Owner:  NLM     Status:  MEDLINE    
In a series of 450 patients with mild essential hypertension, propranolol alone (P), propranolol plus hydrochlorothiazide (P+T), propranolol plus hydralazine (P+H), and propranolol plus hydrochlorothiazide plus hydralazine (P+T+H) were compared to reserpine plus hydrochlorothiazide (R+T). Comparison was based on reduction of diastolic blood pressures (BP) to below 90 mm Hg and at least 5 mm Hg less than initial BP after six months of treatment. This was achieved in 92% of patients who received P+T+H, 88% taking R+T, 81% receiving P+T, 72% on P+H and 52% taking P alone. The number of drop-outs, morbid events, and terminating side effects were insignificantly different among the various regimens. In this study, P and P+H were less effective, while P+T and P+T+H were as effective as the standard regimen.
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  JAMA     Volume:  237     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2303-10     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Clinical Trials as Topic
Drug Synergism
Drug Therapy, Combination
Heart Rate / drug effects
Hydralazine / administration & dosage
Hydrochlorothiazide / administration & dosage
Hypertension / drug therapy*
Middle Aged
Propranolol / administration & dosage*,  adverse effects,  pharmacology
Reserpine / administration & dosage
Vascular Resistance / drug effects
Reg. No./Substance:
0J48LPH2TH/Hydrochlorothiazide; 26NAK24LS8/Hydralazine; 8B1QWR724A/Reserpine; 9Y8NXQ24VQ/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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