| Propranolol in the management of recurrent migraine: a meta-analytic review. | |
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MedLine Citation:
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PMID: 1830566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We used meta-analytic statistical techniques to synthesize findings from studies that evaluated propranolol HCI for the prevention of recurrent migraine (2,403 treated patients). The modal migraine sufferer treated in these studies was a female, about 37 years of age, who suffered from common (rather than classical) migraines and reported a 17-year history of problem migraines. The modal treatment was 160 mg. propranolol per day. Meta-analysis revealed that, on average, propranolol yielded a 44% reduction in migraine activity when daily headache recordings were used to assess treatment outcome, and a 65% reduction in migraine activity when less conservative measures (e.g., clinical ratings of improvement, global patient reports) were used. Meta-analysis thus revealed substantial support for short-term effectiveness of propranolol. However, little information was available concerning the long-term effectiveness of propranolol. |
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Authors:
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K A Holroyd; D B Penzien; G E Cordingley |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Meta-Analysis |
Journal Detail:
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Title: Headache Volume: 31 ISSN: 0017-8748 ISO Abbreviation: Headache Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-09-04 Completed Date: 1991-09-04 Revised Date: 2009-02-02 |
Medline Journal Info:
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Nlm Unique ID: 2985091R Medline TA: Headache Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 333-40 Citation Subset: IM |
Affiliation:
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Institute of Health and Behavioral Sciences, Ohio University, Athens 45701-2979. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Male Meta-Analysis as Topic Migraine Disorders / drug therapy*, physiopathology, prevention & control Prognosis Propranolol / adverse effects, therapeutic use* Recurrence |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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