| (+)-Propranolol clearance, an estimation of hepatic blood flow in man. | |
| | |
MedLine Citation:
|
PMID: 656285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1 Hepatic blood flow was determined before and during (+)- and (+/-)-propranolol plasma concentration plateaus in 19 patients with suspected renal hypertension and normal liver function. 2 Hepatic blood flow significantly decreased (P less than 0.001) during (+/-)-propranolol administration and remained unchanged during (+)-propranolol administration. 3 Hepatic extraction ratio was 74 +/- 1% (+/-)-propranolol and 79 +/- 2% for (+)-propranolol. 4 Total propranolol clearances were determined during the steady-state achieved by a constant infusion. A highly significant positive relationship was observed (r = +0.86; P less than 0.01) between hepatic blood flow and (+)-propranolol clearance. The slope of the curve was 1.05 +/- 0.27. 5 The result implies that the total clearance of (+)-propranolol constitutes an accurate estimation of basal hepatic blood flow in subjects with normal liver function. |
| | |
Authors:
|
Y A Weiss; M E Safar; J P Lehner; J A Levenson; A Simon; J M Alexandre |
Related Documents
:
|
10418205 - Indocyanine green clearance test in non-cirrhotic hepatitis patients: a comparison and ... 9756385 - Effect of increased cardiac output on liver blood flow, oxygen exchange and metabolic r... 2820595 - Galactose loading tests in patients with hepatocellular carcinoma for the assessment of... 3769335 - Hepatic uptake of technetium-99m diphosphonate in thalassemia major. 6495385 - Onchocerciasis in venezuela: prevalence of microfilaraemia in amerindians and morpholog... 20675905 - Influence of hemorheological parameters and mean blood pressure on carotid blood flow a... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of clinical pharmacology Volume: 5 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1978 May |
Date Detail:
|
Created Date: 1978-08-28 Completed Date: 1978-08-28 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 457-60 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Female Hemodynamics Humans Indocyanine Green / diagnostic use Liver Circulation* Male Propranolol / administration & dosage, metabolism* |
| Chemical | |
Reg. No./Substance:
|
3599-32-4/Indocyanine Green; 525-66-6/Propranolol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synov...
Next Document: Influence of soft gelatin on digoxin absorption.