Document Detail


Proposed involvement of adipocyte glyceroneogenesis and phosphoenolpyruvate carboxykinase in the metabolic syndrome.
MedLine Citation:
PMID:  15733733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elevated concentration of plasma non-esterified fatty acids (NEFA) is now recognized as a key factor in the onset of insulin-resistance and type 2 diabetes mellitus. During fasting, circulating NEFAs arise from white adipose tissue (WAT) as a consequence of lipolysis from stored triacylglycerols. However, a significant part of these FAs (30-70%) is re-esterified within the adipocyte, so that a recycling occurs and net FA output is much less than << true >> lipolysis. Indeed, a balance between two antagonistic processes, lipolysis and FA re-esterification, controls the rate of net FA release from WAT. During fasting, re-esterification requires glyceroneogenesis defined as the de novo synthesis of glycerol-3-P from pyruvate, lactate or certain amino acids. The key enzyme in this process is the cytosolic isoform of phosphoenolpyruvate carboxykinase (PEPCK-C; EC 4.1.1.32). Recent advance has stressed the role of glyceroneogenesis and of PEPCK-C in FA release from WAT. Results indicate that glyceroneogenesis is indeed important to lipid homeostasis and that a disregulation in this pathway may have profound pathophysiological effects. The present review focuses on the regulation of glyceroneogenesis and of PEPCK-C gene expression and activity by FAs, retinoic acids, glucocorticoids and the hypolipidemic class of drugs, thiazolidinediones.
Authors:
Thomas Cadoudal; Stéphanie Leroyer; André F Reis; Joan Tordjman; Sylvie Durant; Françoise Fouque; Martine Collinet; Joelle Quette; Geneviève Chauvet; Elmus Beale; Gilberto Velho; Bénédicte Antoine; Chantal Benelli; Claude Forest
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochimie     Volume:  87     ISSN:  0300-9084     ISO Abbreviation:  Biochimie     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-28     Completed Date:  2005-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1264604     Medline TA:  Biochimie     Country:  France    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
Affiliation:
Inserm UMR-S 530; Université Paris5, Centre Universitaire, U.F.R. Biomédicale, 45, rue des Saints-Pères, 75006 Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / metabolism*
Adrenal Cortex Hormones / pharmacology
Animals
Antilipemic Agents / pharmacology
Esterification
Fatty Acids, Nonesterified / blood
Gene Expression Regulation, Enzymologic / drug effects
Glycerol / blood,  metabolism
Glycerophosphates / biosynthesis*
Humans
Metabolic Syndrome X / enzymology,  metabolism*
Mice
Phosphoenolpyruvate Carboxykinase (GTP) / biosynthesis,  metabolism*
Thiazoles / pharmacology
Thiazolidinediones
Tretinoin / pharmacology
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antilipemic Agents; 0/Fatty Acids, Nonesterified; 0/Glycerophosphates; 0/Thiazoles; 0/Thiazolidinediones; 0/Triglycerides; 0/thiazolidine-2,4-dione; 302-79-4/Tretinoin; 56-81-5/Glycerol; EC 4.1.1.32/Phosphoenolpyruvate Carboxykinase (GTP)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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