Document Detail

Proposed interaction between angiotensinogen and retinoblastoma tumor suppressor protein: Potential molecular origin of hypertension.
MedLine Citation:
PMID:  23337794     Owner:  NLM     Status:  In-Data-Review    
Hypertension ranks among the most important disease challenges on a global scale. Here, a novel hypothesis is presented which implicates angiotensinogen, i.e. the precursor protein for the hypertensive peptide angiotensin II, as a key culprit in the pathogenesis of hypertension. This hypothesis more precisely entails that intracellular angiotensinogen binds and thereby inactivates the retinoblastoma tumor suppressor protein (RB), consequently leading to an inflammatory and hyperproliferative state that significantly contributes to pathologically increasing blood pressure. Accordingly, a conceivable antihypertensive strategy could comprise RB-derived compounds that neutralize angiotensinogen.
R T Radulescu
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Bioscience trends     Volume:  6     ISSN:  1881-7823     ISO Abbreviation:  Biosci Trends     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-01-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101502754     Medline TA:  Biosci Trends     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  340-1     Citation Subset:  IM    
Molecular Concepts Research (MCR), Muenster, Germany.
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