| Proposal of a score combining red blood cell indices for early differentiation of beta-thalassemia minor from iron deficiency anemia. | |
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MedLine Citation:
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PMID: 21418745 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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<title/> This study evaluates the diagnostic reliability of 11 red blood cells indices, together with our new index, referred to as '11T', in differentiation of beta-thalassemia minor (BTm) from iron deficiency anemia (IDA). A total of 129 patients with microcytic anemia were involved in a retrospective study, 80 with IDA and 49 with BTm. Using an automatic program, we calculated 11 discrimination indices and a new score, 11T, based on the results of these 11 tests. To confirm the interest of 11T, we performed a prospective study with 53 patients. 11T was most effective in differentiating BTm from IDA: 11T had the highest Youden's index (83%) and the best percentage of correctly identified patients (93%) and gave optimal performance in our prospective study. We proposed a score, 11T, which is able to discriminate between IDA and BTm with high specificity and high sensitivity in order to conduct the appropriate confirmatory examination. |
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Authors:
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Alexandre Janel; Laurence Roszyk; Chantal Rapatel; Gabrielle Mareynat; Marc G Berger; Anne-Françoise Serre-Sapin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hematology (Amsterdam, Netherlands) Volume: 16 ISSN: 1607-8454 ISO Abbreviation: Hematology Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708388 Medline TA: Hematology Country: England |
Other Details:
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Languages: eng Pagination: 123-7 Citation Subset: IM |
Affiliation:
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Hématologie Biologique/Immunologie, CHU, Hôtel Dieu, Boulevard Léon Malfreyt, Clermont Ferrand, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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