| Proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980-2007. | |
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MedLine Citation:
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PMID: 21486978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Given the higher risk of AIDS-defining malignancies that include Kaposi sarcoma (KS), certain non-Hodgkin lymphomas (NHLs), and cervical cancer in persons with human immunodeficiency virus (HIV) infection, the HIV epidemic has likely contributed to the overall numbers of these cancers in the United States. OBJECTIVE: To quantify the proportions of KS, AIDS-defining NHLs, and cervical cancer in the United States that occurred among persons with AIDS from 1980 to 2007. DESIGN, SETTING, AND PARTICIPANTS: The HIV/AIDS Cancer Match Study (1980-2007) linked data from 16 US HIV/AIDS and cancer registries to identify cases with and without AIDS for KS, AIDS-defining NHLs (ie, diffuse large B-cell lymphoma [DLBCL], Burkitt lymphoma [BL], and central nervous system [CNS] lymphoma), and cervical cancer. Using linked data, we derived cancer rates for persons with and without AIDS. To estimate national counts, the rates were applied to national AIDS surveillance and US Census data. MAIN OUTCOME MEASURE: Proportion of AIDS-defining malignancies in the United States occurring in persons with AIDS. RESULTS: In the United States, an estimated 81.6% (95% confidence interval [CI], 81.2%-81.9%) of 83,252 KS cases, 6.0% (95% CI, 5.8%-6.1%) of 351,618 DLBCL cases, 19.9% (95% CI, 18.1%-21.7%) of 17,307 BL cases, 27.1% (95% CI, 26.1%-28.1%) of 27,265 CNS lymphoma cases, and 0.42% (95% CI, 0.37%-0.47%) of 375,452 cervical cancer cases occurred among persons with AIDS during 1980-2007. The proportion of KS and AIDS-defining NHLs in persons with AIDS peaked in the early 1990s (1990-1995: KS, 90.5% [95% CI, 90.2%-90.8%]; DLBCL, 10.2% [95% CI, 9.9%-10.5%]; BL, 27.8% [95% CI, 25.0%-30.5%]; and CNS lymphoma, 48.3% [95% CI, 46.7%-49.8%]; all P < .001 [compared with 1980-1989]) and then declined (2001-2007: KS, 70.5% [95% CI, 68.1%-73.0%]; DLBCL, 4.7% [95% CI, 4.3%-5.2%]; BL, 21.5% [95% CI, 17.7%-25.4%]; and CNS lymphoma, 12.9% [95% CI, 10.5%-15.3%]; all P < .001 [compared with 1990-1995]). The proportion of cervical cancers in persons with AIDS increased over time (1980-1989: 0.11% [95% CI, 0.09%-0.13%]; 2001-2007: 0.71% [95% CI, 0.51%-0.91%]; P < .001). CONCLUSIONS: In the United States, the estimated proportions of AIDS-defining malignancies that occurred among persons with AIDS were substantial, particularly for KS and some NHLs. Except for cervical cancer, the proportions of AIDS-defining malignancies occurring among persons with AIDS peaked in the mid-1990s and then declined. |
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Authors:
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Meredith S Shiels; Ruth M Pfeiffer; H Irene Hall; Jianmin Li; James J Goedert; Lindsay M Morton; Patricia Hartge; Eric A Engels |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: JAMA : the journal of the American Medical Association Volume: 305 ISSN: 1538-3598 ISO Abbreviation: JAMA Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-13 Completed Date: 2011-04-15 Revised Date: 2011-10-14 |
Medline Journal Info:
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Nlm Unique ID: 7501160 Medline TA: JAMA Country: United States |
Other Details:
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Languages: eng Pagination: 1450-9 Citation Subset: AIM; IM |
Affiliation:
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Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7059, Rockville, MD 20892, USA. shielsms@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications* Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Female Humans Infant Lymphoma, AIDS-Related / epidemiology* Male Middle Aged Registries / statistics & numerical data Sarcoma, Kaposi / epidemiology United States / epidemiology Uterine Cervical Neoplasms / epidemiology* |
| Comments/Corrections | |
Comment In:
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JAMA. 2011 Oct 12;306(14):1548
[PMID:
21990297
]
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Erratum In:
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JAMA. 2011 Oct 12;306(14):1548 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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