| Propolis prevents the effects of chronic alcohol intake on ocular tissues. | |
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MedLine Citation:
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PMID: 19628955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: This study is designed to investigate the protective effects of propolis in ocular tissues against chronic alcohol exposure. MATERIAL AND METHOD: Wistar albino rats were used in this study. Rats were divided into 4 groups, and each group was fed a special liquid diet which contained an equal amount of calories. The control group was fed the liquid special diet without alcohol and propolis. We added propolis (150 mg/kg) to the diet of the second group. The diet of the third group contained alcohol, the concentration of which was increased progressively. The fourth group was fed a diet including propolis and alcohol. To counterbalance caloric intake, we decreased the amount of glucose in the special liquid diet for groups 3 and 4. At the end of 30 days, the animals were sacrificed and samples were kept at -80 degrees C until evaluation. Specimens were investigated by light microscopy for morphology and morphometry. RESULTS: In the histological investigation of ocular tissues, alcohol caused an increase in thickness of the cornea and corneal epithelium compared to the control group (p < 0.05). This incremental tendency was significantly reduced by propolis, and values were very close to those of the control group (p > 0.05). Alcohol did not cause any significant alteration of rat retinal thickness. CONCLUSION: This study showed that propolis is highly effective against corneal edema secondary to chronic alcohol intake. |
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Authors:
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Sinan Emre; Zumrut Yilmaz; Feral Ozt??rk; M Hanifi Emre |
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Publication Detail:
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Type: Journal Article Date: 2009-07-23 |
Journal Detail:
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Title: Ophthalmic research Volume: 42 ISSN: 1423-0259 ISO Abbreviation: Ophthalmic Res. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0267442 Medline TA: Ophthalmic Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 147-51 Citation Subset: IM |
Affiliation:
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Research Hospital, Department of Ophthalmology, Celal Bayar University Medical Faculty, Manisa, Turkey. mdsinanemre@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholism
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complications* Animals Anti-Infective Agents / administration & dosage* Cornea / drug effects, pathology Corneal Edema / etiology, pathology, prevention & control* Humans Propolis / administration & dosage* Rats Rats, Wistar Retina / drug effects, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 9009-62-5/Propolis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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