Document Detail

Propofol vs isoflurane anesthesia-incidence of PONV in patients at maxillofacial surgery.
MedLine Citation:
PMID:  20934965     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Prophylaxis of PONV (postoperative nausea and vomiting) is important for maxillofacial surgery. Vomiting is particularly unpleasant for the patient and undesirable as it may be detrimental to the operative area. The aim of this study is to compare the incidence of PONV after propofol with that after isoflurane anesthesia.
MATERIALS AND METHODS: 84 patients age 15-50, ASA I-II, undergoing maxillofacial surgery were randomly allocated in two groups. Group P n=42 -using TIVA (Total Intravenous Anesthesia) with propofol and Group I n=42- using isoflurane anesthesia. The incidence and severity of PONV was evaluated for 24 hours postoperatively based on scoring system: 0=no emetic symptoms, 1=nausea, 2=vomiting. Whereas the severity of nausea was assessed using a four-point Likert scale, with 0=none, 1=mild, 2=moderate, 3=severe.
RESULTS: There were no significant differences between the groups with respect to demographic data and duration of anesthesia. The incidence of nausea (2-3 Likert scale) in the propofol group was 11.9% compared to the isoflurane group 38.1% during early post-operative period (0-6 hrs) (p=0.011), whereas during late post-operative period 7.1% in group P compared with 11.9% in group I (p=0.712).Incidence of vomiting in early post-operative period in-group P was 4.8%, whereas in-group I 11.9% (p=0.432). In late postoperative period in-group P no patient suffered from vomiting or retching, whereas in-group I 4.8% (p=0.494).
CONCLUSIONS: TIVA with propofol reduces the postoperative incidence of nausea and vomiting after maxillofacial surgery, compared with isoflurane anesthesia, and also reduces requirements of antiemetic medications.
A Gecaj-Gashi; M Hashimi; F Sada; N Baftiu; S Salihu; H Terziqi; B Bruqi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Advances in medical sciences     Volume:  55     ISSN:  1898-4002     ISO Abbreviation:  Adv Med Sci     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-04-08     Revised Date:  2012-02-08    
Medline Journal Info:
Nlm Unique ID:  101276222     Medline TA:  Adv Med Sci     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  308-12     Citation Subset:  IM    
Clinic of Anesthesiology & Intensive Care, University Clinical Centre of Kosova, Prishtina, Republic of Kosova.
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MeSH Terms
Isoflurane / adverse effects*,  therapeutic use*
Middle Aged
Nausea / chemically induced
Postoperative Nausea and Vomiting / chemically induced*
Propofol / adverse effects*,  therapeutic use*
Surgery, Oral / methods*
Vomiting / chemically induced
Young Adult
Reg. No./Substance:
2078-54-8/Propofol; 26675-46-7/Isoflurane

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