Document Detail


Propofol versus midazolam: safety and efficacy for sedating the severe trauma patient.
MedLine Citation:
PMID:  9620508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPLICATIONS: In a prospective, controlled, randomized study, we confirmed the safety and efficacy of midazolam and propofol, alone or in combination, in the prolonged sedation of a homogeneous group of severe trauma patients, particularly in patients with head trauma. The propofol group had shorter wake-up times and higher triglyceride levels.
Authors:
J A Sanchez-Izquierdo-Riera; R E Caballero-Cubedo; J L Perez-Vela; A Ambros-Checa; J A Cantalapiedra-Santiago; E Alted-Lopez
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  86     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-06-19     Completed Date:  1998-06-19     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1219-24     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Analgesics, Opioid / therapeutic use
Anesthesia Recovery Period
Blood Pressure / drug effects
Brain / drug effects,  physiology
Craniocerebral Trauma / therapy*
Drug Combinations
Female
Heart Rate / drug effects
Hemodynamics / drug effects
Humans
Hypnotics and Sedatives / administration & dosage,  adverse effects,  therapeutic use*
Incidence
Infusions, Intravenous
Intracranial Pressure / drug effects
Jugular Veins
Male
Midazolam / administration & dosage*,  adverse effects,  therapeutic use*
Morphine / therapeutic use
Oxygen / blood
Propofol / administration & dosage,  adverse effects,  therapeutic use*
Prospective Studies
Respiration, Artificial
Safety
Triglycerides / blood
Wounds and Injuries / therapy*
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 0/Drug Combinations; 0/Hypnotics and Sedatives; 0/Triglycerides; 76I7G6D29C/Morphine; R60L0SM5BC/Midazolam; S88TT14065/Oxygen; YI7VU623SF/Propofol
Comments/Corrections
Comment In:
Anesth Analg. 1999 Nov;89(5):1329-30   [PMID:  10553870 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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