| Propofol pharmacokinetics in children with biliary atresia. | |
| | |
MedLine Citation:
|
PMID: 7880705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We studied the pharmacokinetics of an i.v. bolus dose of propofol 2.5-3.0 mg kg-1 in eight children (age 4-24 months) with biliary atresia and in six control (ASA I) children (age 11-43 months). Blood samples were obtained for 4 h after administration of propofol. Blood concentrations of propofol were measured by high pressure liquid chromatography. Systemic clearance of propofol (CI) and volume of distribution at steady state (Vss) showed a highly significant correlation with body weight. Propofol CI and Vss, normalized for body weight, were similar in children with biliary atresia (mean 37.5 (SD 8.3) ml min-1 kg-1 and 3.5 (1.6) litre kg-1, respectively) compared with control children (38.7 (6.8) ml min-1 kg-1 and 2.4 (0.8) litre-1 kg-1, respectively). We conclude that in children with biliary atresia the pharmacokinetics of propofol are similar to those of healthy children. |
| | |
Authors:
|
A A Raoof; L J van Obbergh; R K Verbeeck |
Related Documents
:
|
2701835 - Optimising oral rehydration solution composition for the children of europe: clinical t... 15527925 - Sweet preferences and sugar consumption of 4- and 5-year-old children: role of parents. 8602665 - Plasma inorganic fluoride concentrations after sevoflurane anesthesia in children. 8659785 - Compound a concentrations during sevoflurane anesthesia in children. 1469105 - 60- and 72-month follow-up of children prenatally exposed to marijuana, cigarettes, and... 1672895 - Dissolution and relative bioavailability of two carbamazepine preparations for children... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of anaesthesia Volume: 74 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1995 Jan |
Date Detail:
|
Created Date: 1995-04-11 Completed Date: 1995-04-11 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 46-9 Citation Subset: IM |
Affiliation:
|
School of Pharmacy, Brussels, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biliary Atresia
/
metabolism* Body Weight Child, Preschool Endoscopy Humans Infant Liver / metabolism* Metabolic Clearance Rate Propofol / blood, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
|
2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spread of subarachnoid hyperbaric amethocaine in adolescents.
Next Document: First-pass pulmonary retention of sufentanil at three different background blood concentrations of t...