Document Detail

Propofol pharmacokinetics in children with biliary atresia.
MedLine Citation:
PMID:  7880705     Owner:  NLM     Status:  MEDLINE    
We studied the pharmacokinetics of an i.v. bolus dose of propofol 2.5-3.0 mg kg-1 in eight children (age 4-24 months) with biliary atresia and in six control (ASA I) children (age 11-43 months). Blood samples were obtained for 4 h after administration of propofol. Blood concentrations of propofol were measured by high pressure liquid chromatography. Systemic clearance of propofol (CI) and volume of distribution at steady state (Vss) showed a highly significant correlation with body weight. Propofol CI and Vss, normalized for body weight, were similar in children with biliary atresia (mean 37.5 (SD 8.3) ml min-1 kg-1 and 3.5 (1.6) litre kg-1, respectively) compared with control children (38.7 (6.8) ml min-1 kg-1 and 2.4 (0.8) litre-1 kg-1, respectively). We conclude that in children with biliary atresia the pharmacokinetics of propofol are similar to those of healthy children.
A A Raoof; L J van Obbergh; R K Verbeeck
Related Documents :
14527745 - A mechanistic mathematical model of temozolomide myelosuppression in children with high...
25252035 - In-group bias in children's intention to help can be overpowered by inducing empathy.
8287045 - Modification of liposomes by addition of hco60. i. targeting of liposomes to liver by a...
808955 - Chloramphenicol metabolism in children with protein-calorie malnutrition.
7090995 - Myocardial injury in infants with congenital heart disease: evaluation by creatine kina...
8657365 - Igf-1 and igfbp-3 screening for disorders of growth hormone secretion.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  74     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-04-11     Completed Date:  1995-04-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  46-9     Citation Subset:  IM    
School of Pharmacy, Brussels, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biliary Atresia / metabolism*
Body Weight
Child, Preschool
Liver / metabolism*
Metabolic Clearance Rate
Propofol / blood,  pharmacokinetics*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Spread of subarachnoid hyperbaric amethocaine in adolescents.
Next Document:  First-pass pulmonary retention of sufentanil at three different background blood concentrations of t...