Document Detail

Propofol pharmacokinetics in children with biliary atresia.
MedLine Citation:
PMID:  7880705     Owner:  NLM     Status:  MEDLINE    
We studied the pharmacokinetics of an i.v. bolus dose of propofol 2.5-3.0 mg kg-1 in eight children (age 4-24 months) with biliary atresia and in six control (ASA I) children (age 11-43 months). Blood samples were obtained for 4 h after administration of propofol. Blood concentrations of propofol were measured by high pressure liquid chromatography. Systemic clearance of propofol (CI) and volume of distribution at steady state (Vss) showed a highly significant correlation with body weight. Propofol CI and Vss, normalized for body weight, were similar in children with biliary atresia (mean 37.5 (SD 8.3) ml min-1 kg-1 and 3.5 (1.6) litre kg-1, respectively) compared with control children (38.7 (6.8) ml min-1 kg-1 and 2.4 (0.8) litre-1 kg-1, respectively). We conclude that in children with biliary atresia the pharmacokinetics of propofol are similar to those of healthy children.
A A Raoof; L J van Obbergh; R K Verbeeck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  74     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-04-11     Completed Date:  1995-04-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  46-9     Citation Subset:  IM    
School of Pharmacy, Brussels, Belgium.
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MeSH Terms
Biliary Atresia / metabolism*
Body Weight
Child, Preschool
Liver / metabolism*
Metabolic Clearance Rate
Propofol / blood,  pharmacokinetics*
Reg. No./Substance:

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