| Propofol inhibits potassium chloride induced contractions of isolated human umbilical vessels. | |
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MedLine Citation:
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PMID: 16438770 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: We have evaluated the effects of propofol and its relationship with K+ channels on human isolated umbilical vessels. METHODS: Umbilical vessel rings were suspended in isolated organ baths containing Krebs-Ringer solution. In the first series of experiments the effect of propofol (10(-9)-10(-4) M) was examined in a concentration-dependent manner on umbilical vessels precontracted with KCl (60 mmol). In the second series, these effects were studied in the presence of tetraethylammonium. RESULTS: A mild contraction was produced by low dose propofol in both precontracted umbilical artery and umbilical vein segments. 10(-4) M propofol caused significant relaxation in both umbilical artery and umbilical vein. The relaxation response was significantly reduced by the addition of 10(-1) M tetraethylammonium. CONCLUSION: These results suggested that the responses of propofol on KCl-induced contractions of both umbilical artery and vein were dose dependent, and this effect involved Ca2+ activated K+ channels. |
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Authors:
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E Caliskan; Z Kayhan; H Tufan |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-01-27 |
Journal Detail:
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Title: European journal of anaesthesiology Volume: 23 ISSN: 0265-0215 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-03-31 Completed Date: 2006-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: England |
Other Details:
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Languages: eng Pagination: 411-7 Citation Subset: IM |
Affiliation:
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Adana Teaching and Medical Research Center, Department of Anaesthesiology, Baskent University, Faculty of Medicine, Adana, Turkey. esra_ertr@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Anesthetics, Intravenous / pharmacology* Calcium Channel Blockers / pharmacology* Calcium Channels / drug effects Dose-Response Relationship, Drug Drug Interactions / physiology Humans Muscle Contraction / drug effects* Muscle, Smooth, Vascular / drug effects Potassium Channel Blockers / pharmacology Potassium Channels / drug effects Potassium Chloride / pharmacology* Propofol / pharmacology* Tetraethylammonium / pharmacology Time Factors Umbilical Arteries / drug effects* Umbilical Cord / blood supply, drug effects Umbilical Veins / drug effects* Vasoconstriction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 0/Calcium Channel Blockers; 0/Calcium Channels; 0/Potassium Channel Blockers; 0/Potassium Channels; 2078-54-8/Propofol; 66-40-0/Tetraethylammonium; 7447-40-7/Potassium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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