Document Detail

Propofol infusion syndrome in a super morbidly obese patient (BMI = 75).
MedLine Citation:
PMID:  22096779     Owner:  NLM     Status:  In-Data-Review    
Propofol infusion syndrome (PRIS) is a rare but often fatal complication as a result of large doses of propofol infusion (4-5 mg/kg/hr) for a prolonged period (>48 h). It has been reported in both children and adults. Besides large doses of propofol infusion, the risk factors include young age, acute neurological injury, low carbohydrate and high fat intake, exogenous administration of corticosteroid and catecholamine, critical illness, and inborn errors of mitochondrial fatty acid oxidation. PRIS manifestation include presence of metabolic acidosis with a base deficit of more than 10 mmol/l at least on one occasion, rhabdomyolysis or myoglobinuria, acute renal failure, sudden onset of bradycardia resistant to treatment, myocardial failure, and lipemic plasma. The pathophysiology of PRIS may be either direct mitochondrial respiratory chain inhibition or impaired mitochondrial fatty acid metabolism mediated by propofol. We report a case of supermorbidly obese patient who received propofol infusion by total body weight instead of actual body weight and developed PRIS.
Ramesh Ramaiah; Loreto Lollo; Douglas Brannan; Sanjay M Bhananker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of critical illness and injury science     Volume:  1     ISSN:  2231-5004     ISO Abbreviation:  Int J Crit Illn Inj Sci     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101571136     Medline TA:  Int J Crit Illn Inj Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  84-6     Citation Subset:  -    
Department of Anesthesiology and Pain Medicine, Harborview Medical Center, University of Washington School of Medicine, Seattle, WA, USA.
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