| Propofol-induced sleep: polysomnographic evaluation of patients with obstructive sleep apnea and controls. | |
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MedLine Citation:
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PMID: 20115978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The localization of upper airway obstruction in patients with obstructive sleep apnea (OSA) may optimize treatment. Nasoendoscopy during propofol sedation allows such an evaluation, but the effect of this drug on respiratory patterns and muscle relaxation is unknown. The objective of the present study was to determine through polysomnography whether propofol would change sleep parameters. STUDY DESIGN: Prospective study of subjects submitted to polysomnography under sedation with propofol. SETTING: Tertiary referral center. SUBJECTS AND METHODS: Fifteen non-obese subjects (4 controls/11 OSA patients) were submitted to two diurnal polysomnograms (90-120 minutes of sleep), with and without the use of propofol. The parameters presence of snoring, apnea-hypopnea index (AHI), oxygen desaturation, and sleep architecture were compared. RESULTS: The use of propofol did not induce snoring in the control subjects, whereas 100 percent of the OSA patients snored. AHI and mean oxygen saturation (SaO(2)) did not differ significantly between examinations with and without sedation. However, minimum SaO(2) differed significantly (P < 0.05) with sedation, being lower during propofol sedation. Propofol also significantly changed the sleep architecture, with a significant increase in N3 sleep (P < 0.005) and total abolishment of rapid eye movement sleep (P < 0.0005) during propofol sedation. CONCLUSIONS: These preliminary results allow us to infer that sedation with propofol changes sleep architecture but permits respiratory evaluation, because the main respiratory parameters evaluated in OSA are maintained. These preliminary results support the view that nasoendoscopy under propofol sedation is a promising examination for management of this disease. |
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Authors:
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F?bio A W Rabelo; Adriano Braga; Daniel S K?pper; Jos? A A De Oliveira; Fernando M Lopes; Pedro Luiz Vaz de Lima Mattos; Shirley G Barreto; Heidi H Sander; Regina M F Fernandes; Fabiana C P Valera |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 142 ISSN: 1097-6817 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-03-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 218-24 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Discipline of Otorhinolaryngology, University of S?o Paulo, S?o Paulo, Brazil. fawrabelo@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Mass Index Case-Control Studies Female Hospitals, University Humans Hypnotics and Sedatives / administration & dosage, therapeutic use* Laryngoscopy / methods Male Middle Aged Oxygen / analysis Polysomnography* Propofol / administration & dosage, therapeutic use* Prospective Studies Severity of Illness Index Sleep Apnea, Obstructive / diagnosis*, physiopathology*, therapy Snoring / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 2078-54-8/Propofol; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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