Document Detail


Propofol displays no protective effect against hypoxia/reoxygenation injury in rat liver slices.
MedLine Citation:
PMID:  12873932     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPLICATIONS: Propofol had no hepatotoxic effect under no-hypoxia conditions in rat liver slices, nor did it have a protective effect against hypoxia/reoxygenation-induced hepatic injury.
Authors:
Hiroo Shimono; Teruko Goromaru; Yoshitami Kadota; Takeshi Tsurumaru; Yuichi Kanmura
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  97     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-22     Completed Date:  2003-08-22     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-8, table of contents     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology and Critical Care Medicine, Kagoshima University School of Medicine, Kagoshima, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenine Nucleotides / metabolism
Adenosine Triphosphate / metabolism
Alanine Transaminase / metabolism
Anesthetics, Intravenous / pharmacology*
Animals
Aspartate Aminotransferases / metabolism
Cell Hypoxia
Culture Media
Energy Metabolism
L-Lactate Dehydrogenase / metabolism
Liver / blood supply,  drug effects,  metabolism*
Male
Oxygen Consumption
Potassium / metabolism
Propofol / pharmacology*
Protective Agents / pharmacology
Rats
Rats, Wistar
Reperfusion Injury / metabolism,  prevention & control*
Chemical
Reg. No./Substance:
0/Adenine Nucleotides; 0/Anesthetics, Intravenous; 0/Culture Media; 0/Protective Agents; 2078-54-8/Propofol; 56-65-5/Adenosine Triphosphate; 7440-09-7/Potassium; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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