Document Detail

Propofol attenuates responses of the auditory cortex to acoustic stimulation in a dose-dependent manner: a FMRI study.
MedLine Citation:
PMID:  15954960     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Functional magnetic resonance imaging (fMRI) using blood-oxygen-level-dependent (BOLD) contrasts is a common method for studying sensory or cognitive brain functions. The aim of the present study was to assess the effect of the intravenous anaesthetic propofol on auditory-induced brain activation using BOLD contrast fMRI. METHODS: In eight neurosurgical patients, musical stimuli were presented binaurally in a block design. Imaging was performed under five conditions: no propofol (or wakefulness) and propofol plasma target concentrations of 0.5, 1.0, 1.5, and 2.0 microg ml(-1). RESULTS: During wakefulness we found activations in the superior temporal gyrus (STG) corresponding to the primary and secondary auditory cortex as well as in regions of higher functions of auditory information processing. The BOLD response decreased with increasing concentrations of propofol but remained partially preserved in areas of basic auditory processing in the STG during propofol 2.0 microg ml(-1). CONCLUSIONS: Our results suggest a dose-dependent impairment of central processing of auditory information after propofol administration. These results are consistent with electrophysiological findings measuring neuronal activity directly, thus suggesting a dose-dependent impairment of central processing of auditory information after propofol administration. However, propofol did not totally blunt primary cortical responses to acoustic stimulation, indicating that patients may process auditory information under general anaesthesia.
M H Dueck; F Petzke; H J Gerbershagen; M Paul; V Hesselmann; R Girnus; B Krug; B Sorger; R Goebel; R Lehrke; V Sturm; U Boerner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  49     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-15     Completed Date:  2005-10-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  784-91     Citation Subset:  IM    
Department of Anaesthesiology, University of Cologne, Cologne, Germany.
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MeSH Terms
Acoustic Stimulation
Anesthesia, General
Anesthesia, Intravenous*
Anesthetics, Intravenous* / blood
Auditory Cortex / drug effects*
Brain Neoplasms / surgery
Data Interpretation, Statistical
Dose-Response Relationship, Drug
Functional Laterality / physiology
Magnetic Resonance Imaging
Middle Aged
Neurosurgical Procedures
Oxygen / blood
Propofol* / blood
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol; 7782-44-7/Oxygen

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