| Propofol anesthesia increases dopamine and serotonin activities at the somatosensory cortex in rats: a microdialysis study. | |
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MedLine Citation:
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PMID: 9174318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to estimate the activities of dopamine and serotonin in animals receiving propofol anesthesia. The in vivo microdialysis technique was used in Sprague-Dawley rats (n = 6) to measure the major metabolites of dopamine and serotonin, i.e. 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (4-hydroxy-3-methyphenylacetic acid; HVA) and 5-hydroxy indole acetic acid (5-HIAA) in the somatosensory cortex. We also measured the levels of propofol in the brain and blood by microdialysis sampling in another group of rats (n = 6). During the experiment, the rat was infused intravenously (IV) with propofol at a rate of 10 mg x kg(-1) x h(-1) for 60 min and 60 mg x kg(-1) x h(-1) for 40 min. We found that IV infusion of propofol at a rate of 60 mg x kg(-1) x h(-1) significantly increased DOPAC, HVA, and 5-HIAA. We also determined that these changes correlated well with propofol levels in the brain and blood. We concluded that anesthetic doses of propofol increased the functional activities of dopamine and serotonin in the cortex. These increases correlate well with propofol levels in the cortex and blood. |
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Authors:
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M H Shyr; T H Tsai; C H Yang; H M Chen; H F Ng; P P Tan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 84 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-06-25 Completed Date: 1997-06-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1344-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia, Chang Gung Memorial Hospital, Chang Gung College of Medicine and Technology, Taoyuan, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Anesthesia* Anesthetics, Intravenous* / pharmacokinetics Animals Dopamine / metabolism* Half-Life Homovanillic Acid / metabolism Hydroxyindoleacetic Acid / metabolism Male Microdialysis Propofol* / pharmacokinetics Rats Rats, Sprague-Dawley Serotonin / metabolism* Somatosensory Cortex / drug effects*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 2078-54-8/Propofol; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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