Document Detail

Propofol and N-Acetylcysteine attenuate oxidative stress induced by intestinal ischemia/reperfusion in rats: protein carbonyl detection by immunoblotting.
MedLine Citation:
PMID:  18797686     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the antioxidant effect of Propofol and N-Acetylcysteine (NAC) on intestinal ischemia/reperfusion (I/R) in rats by determining carbonyl protein level. METHODS: Forty Wistar rats were randomly assigned into the following groups: Control; Sham; I/R with Propofol; I/R with Propofol and NAC; I/R with Ketamine and Xylazine. The I/R groups underwent 60 minutes of ischemia and an equal period of reperfusion. Blood samples, collected by cardiac punction, were centrifuged for plasma obtainment. Protein carbonyl level in plasma samples was determined by immunoblotting. RESULTS: No significant difference in protein carbonyl level was found between Control and Sham groups (P>0.05). The highest reduction in protein carbonyl level (P<0.05) was obtained with the administration of Propofol and NAC (Group 4) in intestinal I/R procedure. CONCLUSION: The administration of Propofol and NAC showed the best antioxidant effect on oxidative stress in rats that underwent intestinal I/R procedure, suggesting a synergistic interaction.
Marcelo Aragão Insuellas de Azeredo; Luciana Aragão Insuellas de Azeredo; Elis Cristina Araújo Eleuthério; Alberto Schanaider
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia     Volume:  23     ISSN:  1678-2674     ISO Abbreviation:  Acta Cir Bras     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-09-17     Completed Date:  2009-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9103983     Medline TA:  Acta Cir Bras     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  425-8     Citation Subset:  IM    
Faculty of Medicine, UFRJ, Rio de Janeiro, Brazil.
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MeSH Terms
Acetylcysteine / pharmacology*
Biological Markers / metabolism
Free Radical Scavengers / pharmacology*
Intestines / blood supply*
Oxidative Stress / drug effects*,  physiology
Propofol / pharmacology*
Protein Carbonylation / physiology*
Rats, Wistar
Reperfusion Injury / metabolism*,  physiopathology
Reg. No./Substance:
0/Biological Markers; 0/Free Radical Scavengers; 2078-54-8/Propofol; 616-91-1/Acetylcysteine

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