Document Detail

Propofol abolished the phrenic long-term facilitation in rats.
MedLine Citation:
PMID:  20038457     Owner:  NLM     Status:  MEDLINE    
The aim was to investigate the effect of propofol anesthesia on the phrenic long-term facilitation (pLTF) in rats. We hypothesized that pLTF would be abolished during propofol-compared with urethane anesthesia. Fourteen adult, male, anesthetized, vagotomized, paralyzed, and mechanically ventilated Sprague-Dawley rats (seven per group), were exposed to the acute intermittent hypoxia (AIH) protocol. Peak phrenic nerve activity (PNA), burst frequency (f), and breathing rhythm parameters (Ti, Te, Ttot) were analyzed during the first hypoxia (TH1), as well as at 15 (T15), 30 (T30), and 60min (T60) after the final hypoxic episode, and compared to the baseline values. In propofol-anesthetized rats no significant changes of PNA were recorded after the last hypoxic episode, i.e. no pLTF was induced. There was a significant increase of PNA (59.4+/-6.6%, P<0.001) in urethane-anesthetized group at T60. AIH did not elicit significant changes in f, Ti, Te, Ttot in either group at T15, T30, and T60. The pLTF, elicited by AIH, was induced in the urethane-anesthetized rats. On the contrary, pLTF was abolished in the propofol-anesthetized rats.
M Carev; M Valic; R Pecotic; N Karanovic; Z Valic; I Pavlinac; Z Dogas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-28
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  170     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  83-90     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier B.V. All rights reserved.
Department of Anesthesiology and Intensive Care, University Hospital Split, Split, Croatia.
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MeSH Terms
Action Potentials / drug effects
Analysis of Variance
Anoxia / pathology,  physiopathology
Electric Stimulation
Hypnotics and Sedatives / pharmacology*
Long-Term Potentiation / drug effects*
Phrenic Nerve / drug effects*
Propofol / pharmacology*
Rats, Sprague-Dawley
Respiration / drug effects
Respiration, Artificial / methods
Time Factors
Tracheotomy / methods
Urethane / pharmacology
Vagotomy / methods
Reg. No./Substance:
0/Hypnotics and Sedatives; 2078-54-8/Propofol; 51-79-6/Urethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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