| Propionylcarnitine excretion is not affected by metronidazole administration to patients with disorders of propionate metabolism. | |
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MedLine Citation:
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PMID: 8750807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Propionylcarnitine (PC) excretion has been measured during a clinical trial of metronidazole therapy in two patients with propionic acidaemia and two patients with methylmalonic aciduria. All patients were in good metabolic control and were receiving L-carnitine. While total propionate excretion was reduced by up to 40% in all four patients during metronidazole therapy, the excretion of propionylcarnitine remained largely unchanged. PC comprised up to 80% of total propionate excretion in patients with propionic acidaemia. CONCLUSION: These results suggest an extra-hepatic source and/or differing compartmentation for PC formation from those for the production of other metabolites of propionyl-CoA. |
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Authors:
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S P Burns; R A Iles; J M Saudubray; R A Chalmers |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pediatrics Volume: 155 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-10-11 Completed Date: 1996-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY |
Other Details:
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Languages: eng Pagination: 31-5 Citation Subset: IM |
Affiliation:
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Medical Unit, London Hospital Medical College, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Metabolism, Inborn Errors
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drug therapy*,
urine Antitrichomonal Agents / pharmacology*, therapeutic use Carnitine / analogs & derivatives*, urine Child, Preschool Humans Infant Magnetic Resonance Spectroscopy Methylmalonic Acid* Metronidazole / pharmacology*, therapeutic use Propionic Acids* |
| Chemical | |
Reg. No./Substance:
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0/Antitrichomonal Agents; 0/Propionic Acids; 17298-37-2/propionylcarnitine; 443-48-1/Metronidazole; 516-05-2/Methylmalonic Acid; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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