| Propionyl l-carnitine: intermittent claudication and peripheral arterial disease. | |
| | |
MedLine Citation:
|
PMID: 19827991 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Peripheral arterial disease (PAD) is a clinical manifestation of underlying aorto-iliac and leg atherosclerosis that is characterized by different stages of stenosis and obstruction. It affects approximately 12% of the adult population and about 20% of people over the age of 70 years, and is associated with increased cardiovascular (CV) and cerebrovascular morbidity. Intermittent claudication (IC) is the major symptom of PAD; it is defined as cramping leg pain (in the buttock, thigh, or calf) while/after clim bing one or two flights of stairs, or during walking. The goals of IC management are to: slow the progression of local and systemic atherosclerosis, prevent major fatal and nonfatal CV events (myocardial infarction and stroke), improve walking capacity, prevent and reduce resting pain and cutaneous lesions. Propionyl L-carnitine is an acyl derivative of levocarnitine (L-carnitine) and is indicated for patients with peripheral arterial occlusive disease. It corrects secondary muscle carnitine deficiency in patients with PAD, significantly improving the walking capacity; it is a free radical that produces positive effects on endothelial function; it protects from oxidative stress; and it enhances most measures of quality of life. The recent Trans-Atlantic Inter-Society Consensus II update recommends the use of propionyl L-carnitine in combination with physical training to improve the symptoms associated with PAD. |
| | |
Authors:
|
G M Andreozzi |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Expert opinion on pharmacotherapy Volume: 10 ISSN: 1744-7666 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-10-30 Completed Date: 2010-01-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
|
Languages: eng Pagination: 2697-707 Citation Subset: IM |
Affiliation:
|
University Hospital, Angiology Care Unit, via Giustiniani 2, Padua 35128, Italy. gm.andreozzi@angio-pd.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cardiotonic Agents
/
pharmacokinetics,
therapeutic use* Carnitine / analogs & derivatives*, pharmacokinetics, therapeutic use Exercise Humans Intermittent Claudication / drug therapy* Peripheral Vascular Diseases / drug therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 17298-37-2/propionylcarnitine; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alpha-1 antitrypsin (AAT) deficiency - what are the treatment options?
Next Document: Pediatric gastroesophageal reflux disease and acid-related conditions: trends in incidence of diagno...