Document Detail

Propionibacterium endocarditis: a case series from the International Collaboration on Endocarditis Merged Database and Prospective Cohort Study.
MedLine Citation:
PMID:  17852887     Owner:  NLM     Status:  MEDLINE    
Propionibacterium species are occasionally associated with serious systemic infections such as infective endocarditis. In this study, we examined the clinical features, complications and outcome of 15 patients with Propionibacterium endocarditis using the International Collaboration on Endocarditis Merged Database (ICE-MD) and Prospective Cohort Study (ICE-PCS), and compared the results to 28 cases previously reported in the literature. In the ICE database, 11 of 15 patients were male with a mean age of 52 y. Prosthetic valve endocarditis occurred in 13 of 15 cases and 3 patients had a history of congenital heart disease. Clinical findings included valvular vegetations (9 patients), cardiac abscesses (3 patients), congestive heart failure (2 patients), and central nervous system emboli (2 patients). Most patients were treated with beta-lactam antibiotics alone or in combination for 4 to 6 weeks. 10 of the 15 patients underwent valve replacement surgery and 2 patients died. Similar findings were noted on review of the literature. The results of this paper suggest that risk factors for Propionibacterium endocarditis include male gender, presence of prosthetic valves and congenital heart disease. The clinical course is characterized by complications such as valvular dehiscence, cardiac abscesses and congestive heart failure. Treatment may require a combination of medical and surgical therapy.
Tahaniyat Lalani; Anna K Person; Susan S Hedayati; Laura Moore; David R Murdoch; Bruno Hoen; Gail Peterson; Hasan Shahbaz; Didier Raoult; Jose M Miro; Lars Olaison; Ulrika Snygg-Martino; Fredy Suter; Dennis Spelman; Susannah Eykyn; Jacob Strahilevitz; Jan T Van der Meer; Dominique Verhagen; Khaula Baloch; Elias Abrutyn; Christopher H Cabell; ;
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  39     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2007  
Date Detail:
Created Date:  2007-12-05     Completed Date:  2007-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  840-8     Citation Subset:  IM    
Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Cube 7545, Durham, NC 27710 USA.
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MeSH Terms
Actinomycetales Infections* / complications,  epidemiology,  microbiology,  physiopathology
Cohort Studies
Databases, Factual
Endocarditis, Bacterial* / complications,  epidemiology,  microbiology,  physiopathology
Heart Diseases / complications,  congenital,  epidemiology,  microbiology
Heart Valve Prosthesis / microbiology
International Cooperation
Middle Aged
Propionibacterium* / classification,  isolation & purification
Prospective Studies
Prosthesis-Related Infections / complications,  epidemiology,  microbiology,  physiopathology
Risk Factors
Survival Rate
Grant Support

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