Document Detail

Propionibacterium acnes and sebaceous lipogenesis: a love-hate relationship?
MedLine Citation:
PMID:  19809423     Owner:  NLM     Status:  MEDLINE    
In this issue, Iinuma et al. show that Propionibacterium acnes (P. acnes)-conditioned medium and formalin-killed P. acnes augment intracellular lipid formation in hamster sebocytes by increasing the de novo synthesis of triacylglycerols. This commentary summarizes the current knowledge of the association of P. acnes with sebaceous lipogenesis, inflammation, and innate immunity, and points out the concurrent evidence that P. acnes-induced lipids may represent a recruitment of allies and/or enemies of the human skin.
Christos C Zouboulis
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  129     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-07     Completed Date:  2009-10-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2093-6     Citation Subset:  IM    
Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany.
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MeSH Terms
Acne Vulgaris / etiology
Corticotropin-Releasing Hormone / physiology
DNA-Binding Proteins / physiology
Immunity, Innate
Inflammation / etiology
Orphan Nuclear Receptors
Propionibacterium acnes / pathogenicity*
Receptors, Cytoplasmic and Nuclear / physiology
Sebaceous Glands / metabolism*
Toll-Like Receptor 2 / physiology
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Orphan Nuclear Receptors; 0/Receptors, Cytoplasmic and Nuclear; 0/Toll-Like Receptor 2; 0/liver X receptor; 9015-71-8/Corticotropin-Releasing Hormone
Comment On:
J Invest Dermatol. 2009 Sep;129(9):2113-9   [PMID:  19282842 ]

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