| Prophylaxis with AT III for thromboembolism in nephrotic syndrome: why should it be done? | |
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MedLine Citation:
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PMID: 18696250 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Children with nephrotic syndrome (NS) are at risk for sinovenous and arterial thrombosis, uncommon but serious complications of the nephrotic syndrome. Multiple factors are involved in the hypercoagulable state of patients with NS, for instance, enhanced platelet reactivity and deficiency of antithrombin III due to urinary loss of this protein. We report the case of a 7-year-old girl with relapse of nephrotic syndrome and with a clinical risk for thromboembolic complications, identified by very low AT III and albumin serum levels and high fibrinogen and cholesterol serum levels. However, having symptoms of hypovolemia, she was treated with albumin and diuretics, known risk factors for thrombotic incidents, although these drugs were both administered after prophylactic intravenous antithrombin. There are no randomized controlled clinical trials supporting prophylactic anticoagulation in the management of nephrotic syndrome. Arterial thromboses during nephrotic syndrome has been associated with thrombophilic states and the use of diuretics. It might be advisable to do laboratory monitoring for coagulation profiling and, in children at risk, prophylactic treatment with AT III before administering albumin infusion and diuretics. |
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Authors:
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Marco Zaffanello; Milena Brugnara; Vassilios Fanos; Massimo Franchini |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-08-12 |
Journal Detail:
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Title: International urology and nephrology Volume: 41 ISSN: 1573-2584 ISO Abbreviation: Int Urol Nephrol Publication Date: 2009 |
Date Detail:
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Created Date: 2009-06-24 Completed Date: 2009-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0262521 Medline TA: Int Urol Nephrol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 713-6 Citation Subset: IM |
Affiliation:
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Department of Mother-Child and Biology-Genetics, University of Verona, Verona, Italy. marco.zaffanello@univr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use* Antithrombin III / therapeutic use* Child Female Humans Nephrotic Syndrome / complications* Thromboembolism / etiology*, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 9000-94-6/Antithrombin III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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