Document Detail

Prophylaxis of venous thromboembolism in minor orthopedic surgery with parnaparin.
MedLine Citation:
PMID:  17636187     Owner:  NLM     Status:  MEDLINE    
This study analyzed the efficacy of venous thromboembolism prophylaxis in knee arthroscopy in 509 patients who received Parnaparin (Alfa Wassermann, Bologna, Italy), 3200 IU to 4250 IU daily, after minor arthroscopic knee surgery. No proximal deep venous thrombosis or other thromboembolic events occurred. Adverse events related to the treatment with Parnaparin were observed in 2 of 172 patients treated with 3200 IU/d and in 6 of 337 patients treated with 4250 IU/d, without any evidence of dose-proportionality in the incidence. Prophylaxis with a low-molecular-weight heparin such as Parnaparin should be considered in all patients who will be undergoing a procedure in which a tourniquet is used. If Parnaparin is used, it should be started immediately after knee arthroscopy at doses of 3200 to 4250 IU/d, according to the characteristics of the patients. Depending on the patient's risk factors, postoperative prophylaxis for 10 days may be appropriate.
Milena Montebugnoli; Stefano Bugamelli; Piero Calò; Elena Zangheri; Patrizio Ferrari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  13     ISSN:  1076-0296     ISO Abbreviation:  Clin. Appl. Thromb. Hemost.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-09-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-58     Citation Subset:  IM    
Servizio di Anestesia e Rianimazione-IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
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MeSH Terms
Anticoagulants / administration & dosage*
Heparin, Low-Molecular-Weight / administration & dosage*
Knee Joint / surgery*
Middle Aged
Prospective Studies
Risk Factors
Thromboembolism / prevention & control*
Venous Thrombosis / prevention & control*
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight; 0/parnaparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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