Document Detail

Prophylaxis and treatment of thrombophilia in pregnancy.
MedLine Citation:
PMID:  16888444     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: This review addresses the prophylaxis and treatment of thrombophilia in pregnancy, which is associated with increased risk of venous thromboembolism and placental vascular complications. RECENT FINDINGS: Topics include preventing deep vein thrombosis recurrence in pregnant women with constitutional thrombophilias, using prophylactic heparins throughout pregnancy and postpartum anticoagulants. Cases of thrombosis still occur in the postpartum period and other therapeutics should be tested. Primary prophylaxis is acceptable for high-risk thrombophilias. Early pregnancy losses (before the 10th week) are not associated with constitutional thrombophilias. The natural prognosis of embryonic losses associated with current thrombogenic polymorphisms is good, unlike fetal losses associated with the same thrombophilias: in this case, a prophylactic low-molecular-weight heparin given from the beginning of the 8th week is more efficient than low-dose aspirin. Data are lacking on the prevention of severe preeclampsia, placental abruption, or intrauterine growth restriction in women with constitutional thrombophilias; preliminary results indicate that low-molecular-weight heparin may have some preventive effect. Specific studies are needed. SUMMARY: Recent studies have shown the limits of available procedures for women with constitutional thrombophilia and have helped define the clinical situations in thrombophilia-related placental insufficiency in which prophylactic low-molecular-weight heparin may be indicated.
Jean-Christophe Gris; Géraldine Lissalde-Lavigne; Isabelle Quéré; Michel Dauzat; Pierre Marès
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in hematology     Volume:  13     ISSN:  1065-6251     ISO Abbreviation:  Curr. Opin. Hematol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-04     Completed Date:  2007-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430802     Medline TA:  Curr Opin Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  376-81     Citation Subset:  IM    
Department of Hematology, University Hospital, Nîmes,
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MeSH Terms
Anticoagulants / therapeutic use*
Heparin, Low-Molecular-Weight / therapeutic use*
Pregnancy Complications, Hematologic / drug therapy*,  prevention & control
Pregnancy Outcome
Thrombophilia / complications,  drug therapy*,  prevention & control
Reg. No./Substance:
0/Anticoagulants; 0/Heparin, Low-Molecular-Weight

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