| Prophylaxis for ribavirin-related anemia using eicosapentaenoic acid in chronic hepatitis C patients. | |
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MedLine Citation:
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PMID: 22375604 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Ribavirin-related anemia is a serious side effect of the pegylated interferon and ribavirin therapy used for hepatitis C, and may be cause for a reduction in ribavirin dose or even cessation of treatment. The aim of this study is to evaluate the prophylactic effects of oral eicosapentaenoic acid (EPA) supplementation on ribavirin-induced hemolytic anemia in pediatric and young adult patients. Methods: Twelve chronic hepatitis C patients ranging in age from 3 to 21 years (mean, 13.9±5.1 years) who received pegylated interferon α-2b and ribavirin combination therapy were randomized to either the control group (n=6) or EPA group (n=6). Blood samples were collected before, and at 4, 8, and 16 weeks after treatment to measure clinical laboratory parameters. Results: The reduction in hemoglobin levels of the EPA group was significantly ameliorated at 8 and 16 weeks when compared to the control group (P<0.05). There was no significant difference in plasma ribavirin concentrations between the two groups during the treatment. However, one patient in the control group had a reduction in ribavirin dose. Conclusion: EPA supplementation prevented ribavirin-induced hemolytic anemia during combination therapy with pegylated IFNα-2b and ribavirin in pediatric and young adult patients. © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society. |
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Authors:
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Mitsuyoshi Suzuki; Eisuke Inage; Kei Minowa; Nobutomo Saito; Nakayuki Naritaka; Mayuko Tsubahara; Yoshikazu Ohtsuka; Akifumi Tokita; Toshiaki Shimizu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-29 |
Journal Detail:
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Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: - ISSN: 1442-200X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society. |
Affiliation:
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Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan Tokita Genki Clinic, Shizuoka, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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