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Prophylaxis for ribavirin-related anemia using eicosapentaenoic acid in chronic hepatitis C patients.
MedLine Citation:
PMID:  22375604     Owner:  NLM     Status:  Publisher    
Background:  Ribavirin-related anemia is a serious side effect of the pegylated interferon and ribavirin therapy used for hepatitis C, and may be cause for a reduction in ribavirin dose or even cessation of treatment. The aim of this study is to evaluate the prophylactic effects of oral eicosapentaenoic acid (EPA) supplementation on ribavirin-induced hemolytic anemia in pediatric and young adult patients. Methods:  Twelve chronic hepatitis C patients ranging in age from 3 to 21 years (mean, 13.9±5.1 years) who received pegylated interferon α-2b and ribavirin combination therapy were randomized to either the control group (n=6) or EPA group (n=6). Blood samples were collected before, and at 4, 8, and 16 weeks after treatment to measure clinical laboratory parameters. Results:  The reduction in hemoglobin levels of the EPA group was significantly ameliorated at 8 and 16 weeks when compared to the control group (P<0.05). There was no significant difference in plasma ribavirin concentrations between the two groups during the treatment. However, one patient in the control group had a reduction in ribavirin dose. Conclusion:  EPA supplementation prevented ribavirin-induced hemolytic anemia during combination therapy with pegylated IFNα-2b and ribavirin in pediatric and young adult patients. © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Mitsuyoshi Suzuki; Eisuke Inage; Kei Minowa; Nobutomo Saito; Nakayuki Naritaka; Mayuko Tsubahara; Yoshikazu Ohtsuka; Akifumi Tokita; Toshiaki Shimizu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-29
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan Tokita Genki Clinic, Shizuoka, Japan.
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