Document Detail


Prophylaxis of infection following colorectal surgery.
MedLine Citation:
PMID:  1816122     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Due to the high incidence of infective complications following colorectal surgery, prophylactic application of systemic antibiotics is required. In a prospective, randomised study of 34 patients who underwent elective colorectal surgery, it was found that a single 1 g dose of cefotaxime was as effective as three doses in controlling post-operative infections. Both groups received 500 mg metronidazole i.v. every 12 h for 72 h, with the first dose administered immediately prior to surgery. The results indicate that prophylactic cefotaxime and metronidazole are effective in reducing the incidence of septic complications following colorectal surgery; nevertheless, a study with a larger number of patients is needed to reach a definitive conclusion.
Authors:
N Rangabashyam; A Rathnasami
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Infection     Volume:  19     ISSN:  0300-8126     ISO Abbreviation:  Infection     Publication Date:    1991 Nov-Dec
Date Detail:
Created Date:  1992-06-26     Completed Date:  1992-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365307     Medline TA:  Infection     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  459-61     Citation Subset:  IM    
Affiliation:
Dept. of Surgical Gastroenterology and Proctology, Governmental General Hospital, Madras, India.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma / microbiology,  surgery
Cefotaxime / therapeutic use*
Colorectal Neoplasms / microbiology,  surgery*
Drug Therapy, Combination
Humans
Leiomyoma / microbiology,  surgery
Metronidazole / therapeutic use*
Middle Aged
Premedication*
Prospective Studies
Surgical Wound Infection / prevention & control*,  surgery
Chemical
Reg. No./Substance:
443-48-1/Metronidazole; 63527-52-6/Cefotaxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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