| Prophylaxis of infection following colorectal surgery. | |
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MedLine Citation:
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PMID: 1816122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Due to the high incidence of infective complications following colorectal surgery, prophylactic application of systemic antibiotics is required. In a prospective, randomised study of 34 patients who underwent elective colorectal surgery, it was found that a single 1 g dose of cefotaxime was as effective as three doses in controlling post-operative infections. Both groups received 500 mg metronidazole i.v. every 12 h for 72 h, with the first dose administered immediately prior to surgery. The results indicate that prophylactic cefotaxime and metronidazole are effective in reducing the incidence of septic complications following colorectal surgery; nevertheless, a study with a larger number of patients is needed to reach a definitive conclusion. |
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Authors:
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N Rangabashyam; A Rathnasami |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Infection Volume: 19 ISSN: 0300-8126 ISO Abbreviation: Infection Publication Date: 1991 Nov-Dec |
Date Detail:
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Created Date: 1992-06-26 Completed Date: 1992-06-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0365307 Medline TA: Infection Country: GERMANY |
Other Details:
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Languages: eng Pagination: 459-61 Citation Subset: IM |
Affiliation:
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Dept. of Surgical Gastroenterology and Proctology, Governmental General Hospital, Madras, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Carcinoma / microbiology, surgery Cefotaxime / therapeutic use* Colorectal Neoplasms / microbiology, surgery* Drug Therapy, Combination Humans Leiomyoma / microbiology, surgery Metronidazole / therapeutic use* Middle Aged Premedication* Prospective Studies Surgical Wound Infection / prevention & control*, surgery |
| Chemical | |
Reg. No./Substance:
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443-48-1/Metronidazole; 63527-52-6/Cefotaxime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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