| Prophylaxis in haemophilia: a double-blind controlled trial. | |
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MedLine Citation:
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PMID: 773416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-blind controlled trial of prophylactic factor VIII therapy has been carried out on nine severe haemophiliacs at the Lord Mayor Treloar College. Infusions were given once weekly and calculated to give a post-infusion plasma concentration of at least 0.25 I.U./ml of factor VIII. This regime reduced the overall bleeding frequency by 15%. The bleeding frequency in the first 3 days post-infusion was reduced by 66%. A moderate overall reduction in morbidity was also achieved. It is calculated that to reduce the incidence of bleeding in severe haemophiliacs by 15% would require a 73% increased usage of therapeutic materials. More than twice this amount of material is likely to be needed to reduce the bleeding frequency of the same group by 66%. |
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Authors:
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A Aronstam; P G Arblaster; S G Rainsford; P Turk; M Slattery; M R Alderson; D E Hall; P J Kirk |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 33 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 1976 May |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 81-90 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Clinical Trials as Topic Dose-Response Relationship, Drug Factor VIII / analysis, therapeutic use* Hemophilia A / complications, drug therapy*, prevention & control Hepatitis / complications Humans Male Morbidity Time Factors |
| Chemical | |
Reg. No./Substance:
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9001-27-8/Factor VIII |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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